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. 2018 Dec 19;2018(12):CD011689. doi: 10.1002/14651858.CD011689.pub3

Comparison 44. Ergometrine vs Misoprostol (by mode of birth).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Death 7 5254 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
1.1 Vaginal birth 7 5254 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
1.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
2 PPH >= 1000 mL 11 5562 Risk Ratio (IV, Random, 95% CI) 1.25 [0.45, 3.48]
2.1 Vaginal birth 11 5562 Risk Ratio (IV, Random, 95% CI) 1.25 [0.45, 3.48]
2.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
3 Blood transfusion 13 5308 Risk Ratio (IV, Random, 95% CI) 1.71 [0.65, 4.50]
3.1 Vaginal birth 13 5308 Risk Ratio (IV, Random, 95% CI) 1.71 [0.65, 4.50]
3.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
4 Severe maternal morbidity: intensive care admissions 1 864 Risk Ratio (IV, Random, 95% CI) 0.33 [0.01, 8.16]
4.1 Vaginal birth 1 864 Risk Ratio (IV, Random, 95% CI) 0.33 [0.01, 8.16]
4.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
5 Severe maternal morbidity: shock 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
5.1 Vaginal birth 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
5.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
6 PPH >= 500 mL 16 6459 Risk Ratio (IV, Random, 95% CI) 1.18 [0.79, 1.75]
6.1 Vaginal birth 16 6459 Risk Ratio (IV, Random, 95% CI) 1.18 [0.79, 1.75]
6.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
7 Additional uterotonics 16 6565 Risk Ratio (IV, Random, 95% CI) 1.04 [0.68, 1.60]
7.1 Vaginal birth 16 6565 Risk Ratio (IV, Random, 95% CI) 1.04 [0.68, 1.60]
7.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
8 Blood loss 15 6337 Mean Difference (IV, Random, 95% CI) 11.66 [‐9.85, 33.17]
8.1 Vaginal birth 15 6337 Mean Difference (IV, Random, 95% CI) 11.66 [‐9.85, 33.17]
8.2 Caesarean 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
9 Change in haemoglobin 8 4438 Mean Difference (IV, Random, 95% CI) 0.91 [‐0.43, 2.26]
9.1 Vaginal birth 8 4438 Mean Difference (IV, Random, 95% CI) 0.91 [‐0.43, 2.26]
9.2 Caesarean 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
10 Breastfeeding 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
10.1 Vaginal birth 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
10.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
11 Nausea 13 5202 Risk Ratio (IV, Random, 95% CI) 1.53 [1.15, 2.04]
11.1 Vaginal birth 13 5202 Risk Ratio (IV, Random, 95% CI) 1.53 [1.15, 2.04]
11.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
12 Vomiting 14 6136 Risk Ratio (IV, Random, 95% CI) 1.22 [0.81, 1.83]
12.1 Vaginal birth 14 6136 Risk Ratio (IV, Random, 95% CI) 1.22 [0.81, 1.83]
12.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
13 Headache 8 3369 Risk Ratio (IV, Random, 95% CI) 1.70 [0.70, 4.12]
13.1 Vaginal birth 8 3369 Risk Ratio (IV, Random, 95% CI) 1.70 [0.70, 4.12]
13.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
14 Abdominal pain 2 233 Risk Ratio (IV, Random, 95% CI) 1.58 [0.04, 65.80]
14.1 Vaginal birth 2 233 Risk Ratio (IV, Random, 95% CI) 1.58 [0.04, 65.80]
14.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
15 Hypertension 2 300 Risk Ratio (IV, Random, 95% CI) 7.55 [0.94, 60.53]
15.1 Vaginal birth 2 300 Risk Ratio (IV, Random, 95% CI) 7.55 [0.94, 60.53]
15.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
16 Shivering 17 6860 Risk Ratio (IV, Random, 95% CI) 0.34 [0.26, 0.44]
16.1 Vaginal birth 17 6860 Risk Ratio (IV, Random, 95% CI) 0.34 [0.26, 0.44]
16.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
17 Fever 14 6330 Risk Ratio (IV, Random, 95% CI) 0.24 [0.17, 0.33]
17.1 Vaginal birth 14 6330 Risk Ratio (IV, Random, 95% CI) 0.24 [0.17, 0.33]
17.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
18 Diarrhoea 8 4165 Risk Ratio (IV, Random, 95% CI) 1.04 [0.46, 2.34]
18.1 Vaginal birth 8 4165 Risk Ratio (IV, Random, 95% CI) 1.04 [0.46, 2.34]
18.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
19 Maternal well‐being 0   Risk Ratio (IV, Random, 95% CI) Totals not selected
19.1 Vaginal birth 0   Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
19.2 Caesarean 0   Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
20 Maternal satisfaction 0   Risk Ratio (IV, Random, 95% CI) Totals not selected
20.1 Vaginal birth 0   Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
20.2 Caesarean 0   Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]