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. 2018 Dec 19;2018(12):CD011689. doi: 10.1002/14651858.CD011689.pub3

Comparison 46. Misoprostol vs Misoprostol plus oxytocin (by mode of birth).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Death 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
1.1 Vaginal birth 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
1.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
2 PPH >= 1000 mL 2 1589 Risk Ratio (IV, Random, 95% CI) 1.85 [1.03, 3.33]
2.1 Vaginal birth 2 1589 Risk Ratio (IV, Random, 95% CI) 1.85 [1.03, 3.33]
2.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
3 Blood transfusion 2 1589 Risk Ratio (IV, Random, 95% CI) 2.97 [1.40, 6.30]
3.1 Vaginal birth 2 1589 Risk Ratio (IV, Random, 95% CI) 2.97 [1.40, 6.30]
3.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
4 Severe maternal morbidity: intensive care admissions 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
4.1 Vaginal birth 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
4.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
5 Severe maternal morbidity:shock 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
5.1 Vaginal birth 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
5.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
6 PPH >= 500 mL 2 1589 Risk Ratio (IV, Random, 95% CI) 1.93 [0.99, 3.76]
6.1 Vaginal birth 2 1589 Risk Ratio (IV, Random, 95% CI) 1.93 [0.99, 3.76]
6.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
7 Additional uterotonics 3 1689 Risk Ratio (IV, Random, 95% CI) 1.89 [1.26, 2.83]
7.1 Vaginal birth 2 1589 Risk Ratio (IV, Random, 95% CI) 2.12 [1.35, 3.32]
7.2 Caesarean 1 100 Risk Ratio (IV, Random, 95% CI) 1.14 [0.45, 2.91]
8 Blood loss 1 792 Mean Difference (IV, Random, 95% CI) 48.0 [24.68, 71.32]
8.1 Vaginal birth 1 792 Mean Difference (IV, Random, 95% CI) 48.0 [24.68, 71.32]
8.2 Caesarean 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
9 Change in haemoglobin 3 1689 Mean Difference (IV, Random, 95% CI) 0.27 [‐0.42, 0.96]
9.1 Vaginal birth 2 1589 Mean Difference (IV, Random, 95% CI) 0.0 [‐1.21, 1.21]
9.2 Caesarean 1 100 Mean Difference (IV, Random, 95% CI) 0.40 [‐0.43, 1.23]
10 Breastfeeding 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
10.1 Vaginal birth 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
10.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
11 Nausea 1 100 Risk Ratio (IV, Random, 95% CI) 1.83 [0.73, 4.57]
11.1 Vaginal birth 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
11.2 Caesarean 1 100 Risk Ratio (IV, Random, 95% CI) 1.83 [0.73, 4.57]
12 Vomiting 3 1689 Risk Ratio (IV, Random, 95% CI) 1.39 [0.51, 3.82]
12.1 Vaginal birth 2 1589 Risk Ratio (IV, Random, 95% CI) 1.03 [0.33, 3.24]
12.2 Caesarean 1 100 Risk Ratio (IV, Random, 95% CI) 4.0 [0.46, 34.54]
13 Headache 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
13.1 Vaginal birth 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
13.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
14 Abdominal pain 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
14.1 Vaginal birth 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
14.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
15 Hypertension 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
15.1 Vaginal birth 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
15.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
16 Shivering 3 1689 Risk Ratio (IV, Random, 95% CI) 0.94 [0.72, 1.22]
16.1 Vaginal birth 2 1589 Risk Ratio (IV, Random, 95% CI) 0.92 [0.71, 1.21]
16.2 Caesarean 1 100 Risk Ratio (IV, Random, 95% CI) 7.0 [0.37, 132.10]
17 Fever 3 1689 Risk Ratio (IV, Random, 95% CI) 0.97 [0.62, 1.53]
17.1 Vaginal birth 2 1589 Risk Ratio (IV, Random, 95% CI) 0.97 [0.61, 1.54]
17.2 Caesarean 1 100 Risk Ratio (IV, Random, 95% CI) 1.0 [0.15, 6.82]
18 Diarrhoea 2 1589 Risk Ratio (IV, Random, 95% CI) 1.22 [0.70, 2.13]
18.1 Vaginal birth 2 1589 Risk Ratio (IV, Random, 95% CI) 1.22 [0.70, 2.13]
18.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
19 Maternal well‐being 0   Risk Ratio (IV, Random, 95% CI) Totals not selected
19.1 Vaginal birth 0   Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
19.2 Caesarean 0   Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
20 Maternal satisfaction 0   Risk Ratio (IV, Random, 95% CI) Totals not selected
20.1 Vaginal birth 0   Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
20.2 Caesarean 0   Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]