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. 2018 Dec 19;2018(12):CD011689. doi: 10.1002/14651858.CD011689.pub3

Comparison 52. Carbetocin vs Ergometrine plus oxytocin (by mode of birth).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Death 2 320 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
1.1 Vaginal birth 2 320 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
1.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
2 PPH >= 1000 mL 4 1210 Risk Ratio (IV, Random, 95% CI) 0.34 [0.13, 0.86]
2.1 Vaginal birth 3 910 Risk Ratio (IV, Random, 95% CI) 0.69 [0.11, 4.38]
2.2 Caesarean 1 300 Risk Ratio (IV, Random, 95% CI) 0.27 [0.09, 0.78]
3 Blood transfusion 4 1030 Risk Ratio (IV, Random, 95% CI) 1.42 [0.42, 4.82]
3.1 Vaginal birth 4 1030 Risk Ratio (IV, Random, 95% CI) 1.42 [0.42, 4.82]
3.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
4 Severe maternal morbidity: intensive care admissions 2 320 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
4.1 Vaginal birth 2 320 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
4.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
5 Severe maternal morbidity: shock 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
5.1 Vaginal birth 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
5.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
6 PPH >= 500 mL 4 1030 Risk Ratio (IV, Random, 95% CI) 0.96 [0.44, 2.09]
6.1 Vaginal birth 4 1030 Risk Ratio (IV, Random, 95% CI) 0.96 [0.44, 2.09]
6.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
7 Additional uterotonics 6 1530 Risk Ratio (IV, Random, 95% CI) 0.54 [0.30, 1.00]
7.1 Vaginal birth 5 1230 Risk Ratio (IV, Random, 95% CI) 0.73 [0.44, 1.21]
7.2 Caesarean 1 300 Risk Ratio (IV, Random, 95% CI) 0.19 [0.08, 0.49]
8 Blood loss 5 1330 Mean Difference (IV, Random, 95% CI) ‐44.08 [‐82.41, ‐5.75]
8.1 Vaginal birth 4 1030 Mean Difference (IV, Random, 95% CI) ‐48.84 [‐94.82, ‐2.85]
8.2 Caesarean 1 300 Mean Difference (IV, Random, 95% CI) ‐24.0 [‐68.42, 20.42]
9 Change in haemoglobin 5 1160 Mean Difference (IV, Random, 95% CI) ‐2.57 [‐4.32, ‐0.82]
9.1 Vaginal birth 4 860 Mean Difference (IV, Random, 95% CI) ‐2.86 [‐4.81, ‐0.90]
9.2 Caesarean 1 300 Mean Difference (IV, Random, 95% CI) ‐1.0 [‐3.83, 1.83]
10 Breastfeeding 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
10.1 Vaginal birth 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
10.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
11 Nausea 6 1530 Risk Ratio (IV, Random, 95% CI) 0.29 [0.19, 0.45]
11.1 Vaginal birth 5 1230 Risk Ratio (IV, Random, 95% CI) 0.27 [0.16, 0.43]
11.2 Caesarean 1 300 Risk Ratio (IV, Random, 95% CI) 0.45 [0.16, 1.28]
12 Vomiting 6 1530 Risk Ratio (IV, Random, 95% CI) 0.27 [0.16, 0.46]
12.1 Vaginal birth 5 1230 Risk Ratio (IV, Random, 95% CI) 0.24 [0.13, 0.44]
12.2 Caesarean 1 300 Risk Ratio (IV, Random, 95% CI) 0.4 [0.13, 1.25]
13 Headache 5 1330 Risk Ratio (IV, Random, 95% CI) 1.41 [0.45, 4.38]
13.1 Vaginal birth 4 1030 Risk Ratio (IV, Random, 95% CI) 0.83 [0.46, 1.49]
13.2 Caesarean 1 300 Risk Ratio (IV, Random, 95% CI) 8.5 [2.00, 36.15]
14 Abdominal pain 4 930 Risk Ratio (IV, Random, 95% CI) 0.57 [0.36, 0.91]
14.1 Vaginal birth 4 930 Risk Ratio (IV, Random, 95% CI) 0.57 [0.36, 0.91]
14.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
15 Hypertension 3 660 Risk Ratio (IV, Random, 95% CI) 0.56 [0.22, 1.39]
15.1 Vaginal birth 3 660 Risk Ratio (IV, Random, 95% CI) 0.56 [0.22, 1.39]
15.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
16 Shivering 5 1290 Risk Ratio (IV, Random, 95% CI) 0.45 [0.26, 0.80]
16.1 Vaginal birth 4 990 Risk Ratio (IV, Random, 95% CI) 0.40 [0.22, 0.74]
16.2 Caesarean 1 300 Risk Ratio (IV, Random, 95% CI) 1.0 [0.21, 4.88]
17 Fever 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
17.1 Vaginal birth 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
17.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
18 Diarrhoea 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
18.1 Vaginal birth 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
18.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
19 Maternal well‐being 0   Risk Ratio (IV, Random, 95% CI) Totals not selected
19.1 Vaginal birth 0   Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
19.2 Caesarean 0   Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
20 Maternal satisfaction 0   Risk Ratio (IV, Random, 95% CI) Totals not selected
20.1 Vaginal birth 0   Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
20.2 Caesarean 0   Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]