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. 2018 Dec 19;2018(12):CD011689. doi: 10.1002/14651858.CD011689.pub3

Comparison 59. Misoprostol vs Placebo or no treatment (by healthcare setting).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Death 4 3497 Risk Ratio (IV, Random, 95% CI) 1.00 [0.10, 9.59]
1.1 Hospital setting 1 100 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
1.2 Community setting 3 3397 Risk Ratio (IV, Random, 95% CI) 1.00 [0.10, 9.59]
2 PPH >= 1000 mL 8 5467 Risk Ratio (IV, Random, 95% CI) 0.73 [0.56, 0.95]
2.1 Hospital setting 5 2114 Risk Ratio (IV, Random, 95% CI) 0.85 [0.63, 1.15]
2.2 Community setting 3 3353 Risk Ratio (IV, Random, 95% CI) 0.59 [0.39, 0.88]
3 Blood transfusion 6 3134 Risk Ratio (IV, Random, 95% CI) 0.46 [0.15, 1.47]
3.1 Hospital setting 5 1514 Risk Ratio (IV, Random, 95% CI) 0.77 [0.19, 3.10]
3.2 Community setting 1 1620 Risk Ratio (IV, Random, 95% CI) 0.14 [0.02, 1.15]
4 Severe maternal morbidity: intensive care admissions 1 1620 Risk Ratio (IV, Random, 95% CI) 1.00 [0.14, 7.05]
4.1 Hospital setting 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
4.2 Community setting 1 1620 Risk Ratio (IV, Random, 95% CI) 1.00 [0.14, 7.05]
5 Severe maternal morbidity: shock 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
5.1 Hospital setting 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
5.2 Community setting 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
6 PPH >= 500 mL 7 4047 Risk Ratio (IV, Random, 95% CI) 0.75 [0.59, 0.94]
6.1 Hospital setting 4 694 Risk Ratio (IV, Random, 95% CI) 0.60 [0.29, 1.25]
6.2 Community setting 3 3353 Risk Ratio (IV, Random, 95% CI) 0.73 [0.56, 0.96]
7 Additional uterotonics 8 3746 Risk Ratio (IV, Random, 95% CI) 0.67 [0.52, 0.87]
7.1 Hospital setting 7 2126 Risk Ratio (IV, Random, 95% CI) 0.68 [0.52, 0.88]
7.2 Community setting 1 1620 Risk Ratio (IV, Random, 95% CI) 0.50 [0.12, 1.98]
8 Blood loss 8 4146 Mean Difference (IV, Random, 95% CI) ‐42.07 [‐52.47, ‐31.68]
8.1 Hospital setting 5 794 Mean Difference (IV, Random, 95% CI) ‐41.82 [‐61.16, ‐22.49]
8.2 Community setting 3 3352 Mean Difference (IV, Random, 95% CI) ‐43.79 [‐58.09, ‐29.49]
9 Change in haemoglobin 5 2334 Mean Difference (IV, Random, 95% CI) ‐2.53 [‐3.53, ‐1.52]
9.1 Hospital setting 3 573 Mean Difference (IV, Random, 95% CI) ‐2.05 [‐4.30, 0.19]
9.2 Community setting 2 1761 Mean Difference (IV, Random, 95% CI) ‐2.12 [‐3.46, ‐0.77]
10 Breastfeeding 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
10.1 Hospital setting 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
10.2 Community setting 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
11 Nausea 4 3997 Risk Ratio (IV, Random, 95% CI) 1.18 [0.78, 1.78]
11.1 Hospital setting 1 600 Risk Ratio (IV, Random, 95% CI) 5.00 [0.59, 42.54]
11.2 Community setting 3 3397 Risk Ratio (IV, Random, 95% CI) 1.12 [0.74, 1.70]
12 Vomiting 6 4949 Risk Ratio (IV, Random, 95% CI) 1.41 [0.92, 2.16]
12.1 Hospital setting 3 1552 Risk Ratio (IV, Random, 95% CI) 2.79 [0.85, 9.15]
12.2 Community setting 3 3397 Risk Ratio (IV, Random, 95% CI) 1.27 [0.80, 2.01]
13 Headache 1 1116 Risk Ratio (IV, Random, 95% CI) 0.94 [0.32, 2.77]
13.1 Hospital setting 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
13.2 Community setting 1 1116 Risk Ratio (IV, Random, 95% CI) 0.94 [0.32, 2.77]
14 Abdominal pain 4 1894 Risk Ratio (IV, Random, 95% CI) 0.98 [0.29, 3.37]
14.1 Hospital setting 4 1894 Risk Ratio (IV, Random, 95% CI) 0.98 [0.29, 3.37]
14.2 Community setting 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
15 Hypertension 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
15.1 Hospital setting 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
15.2 Community setting 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
16 Shivering 9 5286 Risk Ratio (IV, Random, 95% CI) 2.94 [2.38, 3.64]
16.1 Hospital setting 6 1889 Risk Ratio (IV, Random, 95% CI) 3.55 [2.13, 5.90]
16.2 Community setting 3 3397 Risk Ratio (IV, Random, 95% CI) 2.71 [2.33, 3.15]
17 Fever 5 4396 Risk Ratio (IV, Random, 95% CI) 4.09 [2.01, 8.32]
17.1 Hospital setting 2 999 Risk Ratio (IV, Random, 95% CI) 6.38 [4.01, 10.14]
17.2 Community setting 3 3397 Risk Ratio (IV, Random, 95% CI) 2.87 [0.90, 9.18]
18 Diarrhoea 6 4791 Risk Ratio (IV, Random, 95% CI) 2.80 [1.21, 6.49]
18.1 Hospital setting 3 1394 Risk Ratio (IV, Random, 95% CI) 1.0 [0.06, 15.91]
18.2 Community setting 3 3397 Risk Ratio (IV, Random, 95% CI) 3.11 [1.28, 7.51]
19 Maternal well‐being 0   Risk Ratio (IV, Random, 95% CI) Totals not selected
20 Maternal satisfaction 0   Risk Ratio (IV, Random, 95% CI) Totals not selected
20.1 Hospital setting 0   Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
20.2 Community setting 0   Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]