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. 2018 Dec 19;2018(12):CD011689. doi: 10.1002/14651858.CD011689.pub3

Comparison 72. Ergometrine vs Misoprostol (by healthcare setting).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Death 7 5254 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
1.1 Hospital setting 6 4054 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
1.2 Community setting 1 1200 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
2 PPH >= 1000 mL 11 5562 Risk Ratio (IV, Random, 95% CI) 1.25 [0.45, 3.48]
2.1 Hospital setting 10 4362 Risk Ratio (IV, Random, 95% CI) 1.42 [0.47, 4.34]
2.2 Community setting 1 1200 Risk Ratio (IV, Random, 95% CI) 0.33 [0.01, 8.17]
3 Blood transfusion 13 5308 Risk Ratio (IV, Random, 95% CI) 1.71 [0.65, 4.50]
3.1 Hospital setting 12 4108 Risk Ratio (IV, Random, 95% CI) 2.02 [0.73, 5.57]
3.2 Community setting 1 1200 Risk Ratio (IV, Random, 95% CI) 0.33 [0.01, 8.17]
4 Severe maternal morbidity: intensive care admissions 1 864 Risk Ratio (IV, Random, 95% CI) 0.33 [0.01, 8.16]
4.1 Hospital setting 1 864 Risk Ratio (IV, Random, 95% CI) 0.33 [0.01, 8.16]
4.2 Community setting 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
5 Severe maternal morbidity: shock 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
5.1 Hospital setting 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
5.2 Community setting 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
6 PPH >= 500 mL 16 6459 Risk Ratio (IV, Random, 95% CI) 1.18 [0.79, 1.75]
6.1 Hospital setting 15 5259 Risk Ratio (IV, Random, 95% CI) 1.17 [0.77, 1.79]
6.2 Community setting 1 1200 Risk Ratio (IV, Random, 95% CI) 1.25 [0.34, 4.63]
7 Additional uterotonics 16 6565 Risk Ratio (IV, Random, 95% CI) 1.04 [0.68, 1.60]
7.1 Hospital setting 15 5365 Risk Ratio (IV, Random, 95% CI) 1.06 [0.68, 1.65]
7.2 Community setting 1 1200 Risk Ratio (IV, Random, 95% CI) 0.75 [0.17, 3.34]
8 Blood loss 15 6337 Mean Difference (IV, Random, 95% CI) 11.66 [‐9.85, 33.17]
8.1 Hospital setting 14 5137 Mean Difference (IV, Random, 95% CI) 6.55 [‐11.42, 24.51]
8.2 Community setting 1 1200 Mean Difference (IV, Random, 95% CI) 71.30 [60.86, 81.74]
9 Change in haemoglobin 8 4438 Mean Difference (IV, Random, 95% CI) 0.91 [‐0.43, 2.26]
9.1 Hospital setting 8 4438 Mean Difference (IV, Random, 95% CI) 0.91 [‐0.43, 2.26]
9.2 Community setting 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
10 Breastfeeding 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
10.1 Hospital setting 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
10.2 Community setting 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
11 Nausea 13 5202 Risk Ratio (IV, Random, 95% CI) 1.53 [1.15, 2.04]
11.1 Hospital setting 12 4002 Risk Ratio (IV, Random, 95% CI) 1.43 [1.02, 2.00]
11.2 Community setting 1 1200 Risk Ratio (IV, Random, 95% CI) 1.98 [1.49, 2.64]
12 Vomiting 14 6136 Risk Ratio (IV, Random, 95% CI) 1.22 [0.81, 1.83]
12.1 Hospital setting 13 4936 Risk Ratio (IV, Random, 95% CI) 1.26 [0.77, 2.05]
12.2 Community setting 1 1200 Risk Ratio (IV, Random, 95% CI) 1.13 [0.70, 1.83]
13 Headache 8 3369 Risk Ratio (IV, Random, 95% CI) 1.70 [0.70, 4.12]
13.1 Hospital setting 8 3369 Risk Ratio (IV, Random, 95% CI) 1.70 [0.70, 4.12]
13.2 Community setting 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
14 Abdominal pain 2 233 Risk Ratio (IV, Random, 95% CI) 1.58 [0.04, 65.80]
14.1 Hospital setting 2 233 Risk Ratio (IV, Random, 95% CI) 1.58 [0.04, 65.80]
14.2 Community setting 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
15 Hypertension 2 300 Risk Ratio (IV, Random, 95% CI) 7.55 [0.94, 60.53]
15.1 Hospital setting 2 300 Risk Ratio (IV, Random, 95% CI) 7.55 [0.94, 60.53]
15.2 Community setting 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
16 Shivering 17 6860 Risk Ratio (IV, Random, 95% CI) 0.34 [0.26, 0.44]
16.1 Hospital setting 16 5660 Risk Ratio (IV, Random, 95% CI) 0.31 [0.22, 0.44]
16.2 Community setting 1 1200 Risk Ratio (IV, Random, 95% CI) 0.39 [0.33, 0.47]
17 Fever 14 6330 Risk Ratio (IV, Random, 95% CI) 0.24 [0.17, 0.33]
17.1 Hospital setting 13 5130 Risk Ratio (IV, Random, 95% CI) 0.20 [0.15, 0.28]
17.2 Community setting 1 1200 Risk Ratio (IV, Random, 95% CI) 0.45 [0.29, 0.70]
18 Diarrhoea 8 4165 Risk Ratio (IV, Random, 95% CI) 1.04 [0.46, 2.34]
18.1 Hospital setting 8 4165 Risk Ratio (IV, Random, 95% CI) 1.04 [0.46, 2.34]
18.2 Community setting 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
19 Maternal well‐being 0   Risk Ratio (IV, Random, 95% CI) Totals not selected
19.1 Hospital setting 0   Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
19.2 Community setting 0   Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
20 Maternal satisfaction 0   Risk Ratio (IV, Random, 95% CI) Totals not selected
20.1 Hospital setting 0   Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
20.2 Community setting 0   Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]