Acharya 2001.

Methods	2‐arm active‐controlled randomised trial
Participants	60 women were randomised in a hospital setting in UK. The population comprised women of both nulliparous and multiparous, either singleton or multiple pregnancy, at high risk for PPH, who delivered by elective caesarean section. Exclusion criteria were not specified.
Interventions	10 IU of oxytocin administered by an IV bolus versus 400 mcg of misoprostol administered orally
Outcomes	The study recorded the following outcomes: PPH at 1000; additional uterotonics; transfusion; blood loss (mL; change in Hb; vomiting; shivering.
Notes	Contact with study authors for additional information: no. Additional data from authors: no
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Sequence generation was not reported.
Allocation concealment (selection bias)	Low risk	Randomisation was performed using sealed opaque envelopes
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Blinding (of study participants and caregivers) was not reported.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Assessor blinding was not reported.
Objective assessment of blood loss	High risk	Investigators appraised intra‐operative blood loss by the estimation of attending physicians, and by measurement of preoperative and postoperative Hb concentration and hematocrit.
Incomplete outcome data (attrition bias) All outcomes	Low risk	Data were collected completely from all randomised study participants.
Selective reporting (reporting bias)	Unclear risk	The protocol of the study was unavailable for verification.
Intention to treat analysis	Low risk	All those who were enrolled and randomly allocated to treatment were included in the analysis, in the groups to which they were randomised.
Funding source	Unclear risk	Source(s) of funding for the study were not reported.