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. 2018 Dec 19;2018(12):CD011689. doi: 10.1002/14651858.CD011689.pub3

Chua 1995.

Methods 2‐arm active‐controlled randomised trial
Participants 115 women were randomised in a hospital setting in Singapore. The population comprised women of unspecified parity, a singleton pregnancy, at unspecified risk for PPH, who delivered by vaginal delivery. Exclusion criteria were not specified.
Interventions 125 mcg of carboprost administered IM versus 500 mcg plus 5 IU of ergometrine plus oxytocin administered IM
Outcomes The study recorded the following outcomes: additional uterotonics; manual removal of placenta; diarrhoea.
Notes Contact with study authors for additional information: no. Additional data from authors: no
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Randomised by a random number table.
Allocation concealment (selection bias) Unclear risk Allocation concealment was not reported.
Blinding of participants and personnel (performance bias) 
 All outcomes Unclear risk Blinding (of study participants and caregivers) was unclear.
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Assessor blinding was not reported.
Objective assessment of blood loss Low risk All blood and blood clots lost in the first 2 hours after delivery were collected by mopping the blood and clots with absorbent paper, and collect the paper in a plastic bag. The bags were sent to the laboratory for processing within 2 hours of completion of blood collection.
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk 115 women were randomised in the study, but 3 were excluded because they gave birth precipitously before preparing the bed for accurate collection of blood after randomisation.
Selective reporting (reporting bias) Unclear risk The protocol of the study was unavailable for verification.
Intention to treat analysis High risk Those who were excluded from the study after randomisation were not included in the analysis.
Funding source Unclear risk Source(s) of funding for the study were not reported.