| Methods |
2‐arm active‐controlled randomised trial |
| Participants |
60 women were randomised in a hospital setting in Egypt. The population comprised women of unspecified parity, a twin pregnancy, at high risk for PPH, who delivered by elective caesarean section. Exclusion criteria comprised women with hypertension, pre‐eclampsia, cardiac, respiratory, renal or liver disease, pre‐existing bleeding disorder such as haemophilia and women taking therapeutic anticoagulants, hypersensitivity to carbetocin or oxytocin. Patients with Hb less than 9.5 g% and those who are pregnant with more than 2 babies. |
| Interventions |
100 mcg of carbetocin administered by an IV bolus versus 20 IU of oxytocin administered by an IV bolus |
| Outcomes |
The study recorded the following outcomes: additional uterotonics; transfusion; blood loss (mL). |
| Notes |
Contact with study authors for additional information: no. Additional data from authors: no |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
Randomisation was performed by using computer‐generated program. |
| Allocation concealment (selection bias) |
Unclear risk |
Allocation concealment was not reported. |
| Blinding of participants and personnel (performance bias)
All outcomes |
Unclear risk |
Both drugs were prepared preoperatively and coded so that the working investigator and the obstetrician were blinded to the type of drug injected. |
| Blinding of outcome assessment (detection bias)
All outcomes |
Unclear risk |
Assessor blinding was not reported. |
| Objective assessment of blood loss |
Unclear risk |
Methods of evaluating blood loss were not reported. |
| Incomplete outcome data (attrition bias)
All outcomes |
Unclear risk |
The study authors did not mention any incomplete outcome data. |
| Selective reporting (reporting bias) |
Unclear risk |
The protocol of the study was unavailable for verification. |
| Intention to treat analysis |
Unclear risk |
The authors did not specify whether all those who were enrolled and randomly allocated to treatment were included in the analysis, in the groups to which they were randomised. |
| Funding source |
Unclear risk |
Source(s) of funding for the study were not reported. |
