Table 1.
Subject | Sex | Age at Diagnosis (Year) | MPH (SDS) | Puberal Stage | MRI | Treatment Period (Year) | Time Off-Treatment (Year) | Age at Retesting | FH (SDS) | Δ FH-MPH (SDS) | GH-Peak (ng/mL) | IGF-1 (ng/mL) | BMI | BMI (SDS) | Glucid Profile | Lipid Profile |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | F | 12.70 | −0.38 | puberal | small pituitary gland | 3.5 | 0.5 | 16.90 | −0.51 | −0.13 | 32.95 | 237 | 22.10 | 0.35 | N | N |
2 | F | 11.33 | −1.08 | puberal | slightly reduced neurohyp signal. | 4 | 0.33 | 15.84 | −0.81 | 0.27 | 46.75 | 407 | 23.10 | 0.69 | N | N |
3 | M | 5.33 | −1 | pre-puberal | small pituitary gland | 9.33 | 0.25 | 15.04 | −0.03 | 0.97 | 38.74 | 492 | 19.65 | −0.58 | N | N |
4 | M | 10.20 | −0.24 | pre-puberal | normal | 4.5 | 0.42 | 15.11 | 0.1 | 0.34 | 15.45 | 861 | 18.68 | −0.97 | N | N |
5 | M | 11.39 | −0.85 | pre-puberal | normal | 5 | 0.25 | 17.32 | −0.97 | −0.12 | 13.79 | 432 | 18.51 | −1.44 | N | HDL↓ |
6 | M | 13.24 | −0.68 | puberal | normal | 3 | 0.66 | 17 | −0.77 | −0.09 | 43.26 | 371 | 15.73 | −2.98 | N | N |
7 | M | 11.34 | −1.05 | pre-puberal | thin stalk | 4.42 | 0.42 | 16.57 | −2.53 | −1.48 | 28.24 | 478 | 17.89 | −1.62 | N | N |
8 | F | 12.70 | −1.08 | puberal | normal | 3.42 | 0.58 | 16.70 | −1.52 | −0.44 | 35.87 | 586 | 17.32 | −1.81 | N | N |
9 | M | 9.90 | −0.84 | pre-puberal | normal | 5.5 | 0.42 | 14.82 | 0.35 | 1.19 | 24.74 | 390 | 20.21 | −0.34 | N | N |
10 | M | 6.85 | −1.47 | pre-puberal | partial empty saddle | 8.92 | 0.33 | 16.20 | −1.68 | −0.21 | 59.02 | 317 | 19.43 | −0.86 | N | N |
11 | F | 4.20 | −1.89 | pre-puberal | normal | 7.42 | 0.50 | 12.10 | −1.14 | 0.75 | 25.94 | 437 | 20.59 | 0.22 | N | TG and LDL↑ |
12 | F | 9.22 | −0.44 | pre-puberal | normal | 4.5 | 0.50 | 14.20 | −0.35 | 0.09 | 66.43 | 364 | 16.76 | −1.79 | N | N |
13 | M | 12.35 | −0.85 | pre-puberal | small pituitary gland | 3 | 0.66 | 16.21 | −1.45 | −0.6 | 40.51 | 349 | 19.78 | −0.72 | N | N |
14 | M | 10 | −1.08 | pre-puberal | small pituitary gland | 5.5 | 0.66 | 16.20 | −0.08 | 1 | 35.30 | 440 | 19.27 | −0.92 | N | N |
15 | M | 13.92 | −0.90 | puberal | slight-asymmetry of pituitary gland | 2 | 0.33 | 16.41 | −0.95 | −0.05 | 42.27 | 443 | 20.22 | −0.97 | N | N |
16 | F | 9.97 | −0.44 | pre-puberal | small pituitary gland | 5.42 | 0.33 | 16.80 | −0.29 | 0.15 | 50.49 | 490 | 25.62 | 1.32 | N | N |
17 | M | 8.67 | −0.46 | pre-puberal | normal | 4.5 | 0.25 | 14.90 | −0.33 | 0.13 | 34.40 | 353 | 22.05 | 0.25 | N | N |
18 | F | 9.64 | 0.92 | pre-puberal | small pituitary gland | 4.33 | 0.42 | 14.83 | 0.10 | −0.82 | 36.30 | 494 | 17.23 | −1.64 | N | N |
19 | M | 14.44 | −0.85 | puberal | partial empty saddle | 2.5 | 0.58 | 17.85 | −0.46 | 0.39 | 0.44 | 460 | 22.32 | 0.11 | N | N |
20 | F | 9.79 | −1.38 | pre-puberal | small pituitary gland | 5 | 0.33 | 15.31 | −2.79 | −1.41 | 58.63 | 498 | 26.45 | 1.50 | N | N |
21 | M | 11.64 | −0.93 | pre-puberal | normal | 5.5 | 0.25 | 17.40 | −0.55 | 0.38 | 45.54 | 407 | 20.09 | −0.72 | N | N |
22 | M | 6.22 | 0.41 | pre-puberal | normal | 8.92 | 0.42 | 15.73 | −0.61 | −1.02 | 44.99 | 173 | 17.27 | −1.64 | N | N |
23 | F | 11.11 | −0.68 | pre-puberal | small pituitary gland | 3 | 0.42 | 14.95 | −1.38 | −0.7 | 96.64 | 730 | 20.40 | −0.22 | N | N |
24 | M | 12.95 | −1.71 | pre-puberal | normal | 3.5 | 0.33 | 16.92 | −0.98 | 0.73 | 35.30 | 379 | 19.10 | −1.10 | N | N |
25 | F | 11.71 | −0.85 | puberal | normal | 4 | 0.50 | 16.64 | −1.27 | −0.42 | 4.64 | 269 | 26.78 | 1.56 | N | TC↑ |
26 | F | 7.74 | −0.96 | pre-puberal | normal | 7.5 | 0.33 | 15.7 | −0.71 | 0.25 | 55.64 | 286 | 21.37 | 0.13 | N | N |
27 | F | 10.66 | −1.12 | puberal | partial empty saddle | 3.5 | 0.42 | 16.64 | −1.13 | −0.01 | 25.46 | 386 | 22.01 | 0.36 | N | N |
28 | M | 5.47 | −0.77 | pre-puberal | normal | 10.2 | 0.33 | 15.94 | −0.06 | 0.71 | 16.68 | 453 | 16.35 | −2.30 | N | N |
29 | M | 3.34 | −0.86 | pre-puberal | thin stalk | 13 | 0.42 | 15.70 | −0.64 | 0.22 | 39.32 | 287 | 21.44 | −0.04 | N | N |
30 | M | 12 | −1.51 | pre-puberal | normal | 4.75 | 0.33 | 17.33 | −0.71 | 0.8 | 46.21 | 444 | 22.23 | 0.09 | N | N |
31 | M | 12.17 | −1.63 | pre-puberal | normal | 3.6 | 0.33 | 17.17 | −1.89 | −0.26 | 20.40 | 272 | 25.97 | 1.17 | N | N |
HDL, cholesterol high-density lipoprotein; LDL, cholesterol low-density lipoprotein; N, normal; TG, triglycerides.