Table A2.
Parameter estimates for the within- between-subject decomposition regression of Table 2 EGFR = HIV infection, albumin and BUN in the Bronx WIHS using mixed models.
| Variable | Compartment | Working Correlation Structure | |||||
|---|---|---|---|---|---|---|---|
| Independence | Equicorrelation | ||||||
| Point Estimate | 95% CI 1 | Z-Value (p) 1 | Point Estimate | 95% CI 1 | Z-Value (p) 1 | ||
| HIV Infection | Between-subject (βHIV,BS) |
−1.16 | (−4.21, 1.88) | −2.30 (0.02) |
−1.57 | (−4.47, 1.32) | −1.06 (0.29) |
| NA 2 | --- | --- | --- | NA 2 | --- | --- | |
| Albumin Per g/dL |
Between-subject (βALB,BS) |
−3.28 | (−4.78, −1.77) |
−4.26 (0.16) |
−2.72 | (−7.00, 1.57) |
−1.32 (0.19) |
| Within-subject (βALB,WS) |
−10.70 | (−12.24, −9.15) |
13.60 (<0.0001) | −10.67 | (−11.86, −9.48) |
−17.57 (<0.0001) | |
| BUN Per mg/dL | Between-subject (βBUN,BS) |
−2.72 | (−2.84, −2.60) |
−44.87 (<0.0001) |
−2.65 | (−2.95, −2.35) |
−17.10 (<0.0001) |
| Within-subject (βBUN,WS) |
−1.11 | (−1.22, −0.99) |
−18.59 (<0.0001) | −1.11 | (−1.20, −1.03) |
−25.72 (<0.0001) | |
| Akaike Information Criteria (AIC) | 98,451.8 | 94,824.7 | |||||
1 The confidence interval and p-values for independence working correlation structure in particular but also arguably for equicorrelation overestimate the precision of the parameter estimates. Unlike GEE, mixed models are not robust to misspecification of the correlation structure. 2 There is no Within-subject Variation for HIV Infection Status.