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TEMPO and its derivatives cause DNA-strand breaks in mouse lymphoma cells. Following a 4-h treatment, DNA single- and double-strand breaks induced by 4 nitroxides were evaluated by Comet assay. (A) TEMPO; (B) 4-hydroxy-TEMPO; (C) 4-oxo-TEMPO; (D) 4-methoxy-TEMPO. The data points represent the mean ± SD from 3 independent experiments. * p < .05 compared with the vehicle control.
