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. Author manuscript; available in PMC: 2019 Feb 25.
Published in final edited form as: Toxicol Sci. 2018 May 1;163(1):214–225. doi: 10.1093/toxsci/kfy022

Figure 4.

Figure 4.

Mutational spectra evaluated by LOH analysis in induced Tk mutants at 5 heterozygous loci along mouse chromosome 11. Following 11 days incubation, the mutants were collected from TFT-selective plates in the MLA. The data were the weighted sum of mutation percentages from large and small colony mutants. The “–” indicates the LOH extends from the Tk locus to either D11Mit42, D11Mit36, D11Mit20, or D11Mit74. (A) Treatment without S9; (B) Treatment with S9; (C) The loci that were analyzed for LOH are marked on the chromosome 11.