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. Author manuscript; available in PMC: 2019 Feb 25.
Published in final edited form as: Toxicol Sci. 2018 May 1;163(1):214–225. doi: 10.1093/toxsci/kfy022

Figure 7.

Figure 7.

Comparison of BMD values for the mutagenicity and DNA damaging effects induced by TEMPO and its derivatives. The BMD (BMD5, BMD10, BMD50, BMD100, and BMD200) estimates producing a 5%, 10%, 50%, 100%, or200% increase in the background responses were calculated using Hill model of PROAST with covariate analysis approach. Top panel, treatments without S9 in the MLA; middle panel, treatments with S9 in the MLA; bottom panel, data from the Comet assay. The bars represent the calculated lower and upper 95% CI of each value.