Table 1.
Criteria for Classification of Chemical’s MoAa
| GEFsb |
|||
|---|---|---|---|
| Treatments | Biomarkers | Clastogen | Aneugen |
| 4-h | γ-H2AX | 1.51-fold | |
| p53 | 1.40-fold | ||
| p-H3 | 1.71-fold | ||
| 24-h | γ-H2AX | 2.11-fold | |
| p53 | 1.45-fold | 1.45-fold | |
| p-H3 | 1.52-fold | ||
| polyploidy | 5.86-fold | ||
a
From Bryce et al. (2017). All assay data were restricted to ≤80% cytotoxicity following a 24-h treatment, which was evaluated by relative nuclei counts (≥20%) at the highest concentration.
b
GEFs, expressed as fold-increase over concurrent solvent controls, were generated from pooled fold-increase response data for a total of 84 chemicals studied across 7 laboratories in the world.