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IC20 Values of TEMPO and 3 oflts Derivativesa
| Nitroxide | MTS assay (mM) |
Blue assay (mM) |
ATP assay (mM) |
|---|---|---|---|
| TEMPO | 0.011 | 4.968 | 1.923 |
| 4-hydroxy-TEMPO | 0.356 | 1.781 | 6.389 |
| 4-oxo-TEMPO | 1.553 | 1.950 | 1.730 |
| 4-methoxy-TEMPO | 0.030 | 2.577 | 3.874 |
L5178Y mouse lymphoma cells were treated with the 4 nitroxides at various concentrations and cell viabilities were measured. IC20 values were calculated by Nonlinear Regression (Curve fit) using Graphpad Prism 6 software.
