. Author manuscript; available in PMC: 2019 Feb 25.

Published in final edited form as: Toxicol Sci. 2018 May 1;163(1):214–225. doi: 10.1093/toxsci/kfy022

Table 3.

Relative Genotoxic Potential of 4 Nitroxides

	MLA Without S9		MLA With S9		Comet Assay
Nitroxide	BMDL₁₀^a	Ranking	BMDL₁₀^a	Ranking	BMDL₁₀^a	Ranking

TEMPO	0.981	3	0.257	2	0.454	1
4-hydroxy-TEMPO	1.300	4	1.024	4	1.612	3
4-oxo-TEMPO	0.661	1	0.058	1	1.114	2
4-methoxy-TEMPO	0.756	2	0.770	3	3.358	4

BMDL₁₀, the lower limit of the 10% BMD, is calculated from Hill model of the PROAST Software using chemical as a covariate for both the MLA MF data and the %DNA in tail data from the Comet assay.