Table 2.
Changes in β2-MG and P-SEP levels during HD using high-flux dialysis membranes with a β2-MG clearance ≥50 mL/min
| 0 h | 2 h | 4 h | R (2 h) | R (4 h) | |
|---|---|---|---|---|---|
| β2-MG, mg/L | 26.3 (24.6–28.4) | 12.6 (10.5–15.2)** | 9.1 (7.7–11.5)** | 55.7±7.4 | 69.1±7.1 |
| P-SEP, pg/mL | 1,295 (988–1,928) | 801 (684–1,108) | 667 (463–750)* | 42.8±7.9 | 58.8±18.4 |
| Ht, % | 36.1±3.5 | 38.3±3.5 | 39.9±3.2 |
Blood samples were collected before HD (0 h) and at 2 or 4 h after starting HD. The membranes used in the present study were a Hollow fiber dialyzer FD series (FDY-180GW; polyester polymer alloy [PEPA®]; class IV; NIKKISO Co., Ltd., Tokyo, Japan) (n = 2), a Triacetate hollow fiber dialyzer FB-eco series (FB-190Pβeco; cellulose triacetate [CTA]; class IV; Nipro Co., Ltd, Osaka, Japan) (n = 2), a Toraylight® NV (NV-21X; polysulfone [PS]; class V; TORAY Industries, Inc., Tokyo, Japan) (n = 2), and a PEPA dialyzer FDW (FDW-18; [PEPA®]; class V; NIKKISO Co., Ltd.) (n = 2). β2-MG, β2-microglobulin; P-SEP, presepsin; HD, hemodialysis; R, removal ratio; Ht, hematocrit.
p < 0.05 versus 0 h
p < 0.01 versus 0 h, Kruskal-Wallis test with Steel-Dwass correction.