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. 2019 Feb 25;39:4. doi: 10.1186/s41232-019-0093-1

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Approaches for HF regeneration using of human induced pluripotent stem cells (hiPSCs). Currently, two respective approaches exist. In the “classic” approach, epithelial and mesenchymal components optimized for trichogenic EMIs are prepared and combined in vivo to form HF structures. Another approach takes advantage of pluripotency of hiPSCs, 3D integumentary organ systems with HFs are microdissected from cystic structures generated by grafting hiPSCs in vivo. HFs can be dissected from 3D integumentary organ systems for downstream applications including hair transplantation