Table II.
Different serum levels of inflammatory cytokines between GC patients and healthy controls.
| Cytokines | Controls (n=98) | GC patients (n=142) | Z (P) | Crude OR (95% CI) | Adjusted OR (95% CI) |
|---|---|---|---|---|---|
| GM-CSF | 0.078 (0.040,0.159) | 0.130 (0.070,0.192) | 2.705 (0.007) | 1.026 (0.801,1.315) | 1.025 (0.800,1.313) |
| IL-1α | 0.275 (0.000,1.067) | 0.062 (0.000,0.845) | 2.227 (0.026) | 0.956 (0.904,1.010) | 0.956 (0.904,1.010) |
| IL-5 | 0.372 (0.110,0.638) | 0.181 (0.000,0.689) | 2.449 (0.014) | 0.946 (0.697,1.284) | 0.940 (0.689,1.282) |
| IL-7 | 15.126 (10.474,18.481) | 12.368 (8.545,17.327) | 2.537 (0.011) | 0.971 (0.938,1.005) | 0.973 (0.939,1.007) |
| IL-12/IL-23P40 | 124.390 (87.194,158.732) | 156.749 (117.702,216.779) | 4.216 (0.000) | 1.007 (1.003,1.011) | 1.007 (1.003,1.011) |
| IL-15 | 2.431 (2.007,2.799) | 2.576 (2.180,2.969) | 2.251 (0.024) | 1.597 (1.076,2.372) | 1.597 (1.073,2.377) |
| IL-16 | 199.825 (155.470,275.296) | 193.108 (127.628,285.028) | 0.687 (0.492) | 1.000 (0.999,1.002) | 1.000 (0.999,1.002) |
| IL-17α | 1.907 (1.345,2.995) | 3.161 (2.144,4.950) | 6.114 (0.000) | 1.074 (0.986,1.170) | 1.077 (0.986,1.176) |
| TNF-β | 0.230 (0.167,0.289) | 0.182 (0.140,0.222) | 3.873 (0.000) | 0.575 (0.155,2.135) | 0.580 (0.155,2.172) |
| VEGF | 155.768 (102.168,225.789) | 118.124 (82.551,202.478) | 2.109 (0.035) | 0.999 (0.997,1.001) | 0.999 (0.997,1.001) |
| IFN-γ | 5.432 (3.869,8.165) | 7.272 (5.192,11.221) | 3.820 (0.000) | 1.017 (0.993,1.043) | 1.017 (0.992,1.043) |
| IL-1β | 0.000 (0.000,0.263) | 0.234 (0.000,0.904) | 2.747 (0.006) | 1.013 (0.979,1.048) | 1.013 (0.979,1.048) |
| IL-2 | 0.183 (0.082,0.323) | 0.297 (0.181,0.474) | 3.889 (0.000) | 1.627 (0.881,3.004) | 1.604 (0.871,2.956) |
| IL-4 | 0.010 (0.002,0.019) | 0.006 (0.000,0.019) | 1.196 (0.232) | 36.495 (0.009,146.427) | 40.263 (0.009,180.906) |
| IL-6 | 0.791 (0.499,1.555) | 1.739 (0.927,3.725) | 5.321 (0.000) | 0.996 (0.987,1.005) | 0.996 (0.987,1.005) |
| IL-8 | 42.301 (23.698,110.848) | 105.243 (47.510,259.504) | 4.876 (0.000) | 1.000 (1.000,1.001) | 1.000 (1.000,1.001) |
| IL-10 | 0.380 (0.261,0.505) | 0.571 (0.381,0.865) | 5.189 (0.000) | 2.711 (1.317,5.579) | 2.693 (1.306,5.554) |
| IL-12p70 | 0.109 (0.039,0.170) | 0.198 (0.089,0.372) | 4.304 (0.000) | 1.376 (0.858,2.206) | 1.372 (0.858,2.194) |
| IL-13 | 0.684 (0.163,1.653) | 0.866 (0.294,1.390) | 0.561 (0.575) | 1.044 (0.891,1.224) | 1.042 (0.889,1.221) |
| TNF-α | 3.126 (2.491,3.961) | 4.347 (3.342,5.788) | 5.495 (0.000) | 1.016 (0.978,1.055) | 1.015 (0.978,1.054) |
Data for the serum concentrations of inflammatory cytokines are presented as the Median (P25, P75) pg/ml. The OR values were adjusted by age and sex. GC, gastric cancer; GM-CSF, granulocyte-macrophage colony-stimulating factor; IL-, interleukin; TNF-α, tumor necrosis factor-α; VEGF, vascular endothelial growth factor; IFN-γ, interferon-γ.