Fig. 1.

Differential concentrations of soluble inflammatory mediators (SIMs) in patients with liver cirrhosis relative to healthy donors. The concentrations of 50 SIMs were measured in the plasma from cirrhosis patients without any detectable tumors prior to antiviral therapy (n = 24) as well as from healthy individuals (n = 10) using the multiplex assay. a Principal component analysis plot showing the distinct clustering at baseline based on the differential levels of the SIMs measured. SIMs that significantly increased (top panel) or decreased (lower panel) are accordingly indicated. b The relative SIM profiles of the cirrhosis patients with respect to normal levels in healthy individuals. Principal component analysis was performed using Qlucore Omics explorer Software v2.2 (Qlucore AB, Lund, Sweden). A t test was used for the 2-group comparison.