TABLE 4.

Estimates of the Kinetic Parameters

Pathway	Parameter	Estimated value	Source
Stimulus	k1	7.5 s−1 μM−1	van Haastert and de Wit [49]
	k−1	0.45 s−1	van Haastert and de Wit [49]
	k2	1.0 × 103 m2/(μmol·s)	Gilman [21]
	k−2	0.0 s−1	Gilman [21]
	k3	1.0 × 103 s−1	Gilman [21]
	k4	1.0 × 104 m2/(μmol·s)
	k−4	0.0 s−1
	k5	0.0625 s−1	Gilman [21]
	k6	1.0 × 105 m2/(μmol·s)
Inhibitory	h1	2.2 s−1 μM−1	van Haastert and de Wit [49]
	h−1	1.0 s−1	van Haastert and de Wit [49]
	h2	40.0 m2/(μmol·s)	Dinauer et al. [13]
	h−2	0.0 s−1	Dinauer et al. [13]
	h3	4.0 × 102 s−1	Dinauer et al. [13]
	h4	5.0 × 106 m2/(μmol·s)
	h−4	0.0 s−1
	h5	7.5 × 10−3 s−1	Gerisch and Wick [20]
	h6	17.0 s−1	van Haastert and de Wit [49]
	h7	105 m2/(μmol·s)
cAMP generation and secretion	l	20.2 s−1	Levitzki [29]
	l−1	20.2 s−1	Levitzki [29]
	l2	202 s−1	Levitzki [29]
	l3	5.0 × 10−4 m3/(μmol·s)	Rapp et al. [37]
	l−3	0.0 s−1	Rapp et al. [37]
	l4	50 s−1	Rapp et al. [37]
	l5	0.157 s−1