Table 3.
Results of SUR analysis on testing the effect of diagnosis in 29 groups of biologically related metabolites
| Group number (# metabolites) | Biological connection/pathway | p value | Adjusted p value (BH)* |
|---|---|---|---|
| 1 (9) | Glycolysis/gluconeogenesis | 4.72e−05 | 9.74e−05 |
| 2 (6) | Valine/leucine/isoleucine biosynthesis | 0.023 | 0.027 |
| 3 (10) | Alanine/aspartate/glutamate metabolism | 1.28e−08 | 3.84e−08 |
| 4 (10) | Arginine/proline metabolism | 2.97e−08 | 8.17e−08 |
| 5 (3) | Histidine metabolism | 1.76e−09 | 8.30e−09 |
| 6 (4) | Propionate metabolism | 0.099 | 0.11 |
| 7 (6) | Tyrosine metabolism | 0.059 | 0.067 |
| 8 (10) | Glyoxalate and dicarboxylate metabolism | 5.20e−05 | 1.01e−04 |
| 9 (6) | Phenylalanine/tyrosine/ tryptophan metabolism | 5.47e−06 | 1.20e−05 |
| 10 (12) | Glycolysis/TCA cycle | 1.44e−06 | 3.39e−06 |
| 11 (9) | Glycine/serine/threonine metabolism | 9.21e−05 | 1.69e−04 |
| 12 (8) | TCA cycle | 0.0035 | 0.0050 |
| 13 (8) | Glycolysis | 1.35e−04 | 2.34e−04 |
| 14 (7) | Gluconeogenesis | 3.25e−04 | 5.36e−04 |
| 15 (9) | Urea cycle | 2.78e−09 | 1.02e−08 |
| 16 (19) | Amino acids | 2.11e−12 | 2.32e−11 |
| 17 (51) | Amino acid metabolism | 0 | 0 |
| 18 (18) | Nucleotide metabolism | 1.41e−10 | 7.76e−10 |
| 19 (13) | Purine metabolism | 1.44e−11 | 9.50e−11 |
| 20 (6) | Pyrimidine metabolism | 6.58e−09 | 2.17e−08 |
| 21 (4) | Bile acid metabolism | 0.21 | 0.22 |
| 22 (5) | Carbohydrate | 0.006 | 0.0083 |
| 23 (10) | Lipids pathway | 3.15e−07 | 8.00e−07 |
| 24 (4) | Vitamins | 0.0028 | 0.0042 |
| 25 (3) | Microbial metabolism | 0.0071 | 0.0094 |
| 26 (6) | Tryptophan metabolism | 0.022 | 0.027 |
| 27 (7) | Methionine metabolism | 0.0024 | 0.0038 |
| 28 (4) | Organic acids | 0.021 | 0.027 |
| 29 (2) | Ketone bodies | 0.13 | 0.14 |
See Supplemental Information Table S3 for metabolite groupings
*
Benjamini–Hochberg FDR correction