Table 1.
Year | Rad Dose (Gy) |
LDXX/30 (expected)a |
LDXX/30 (actual) |
No. of miceb |
Fig. 1A (Wt.) |
Figs. 1B-F (CBC) |
Fig. 2 (BM) |
Fig. 3 (HSC trpl.) |
Figs. 4A-E (Culture) |
Figs. 4F-H (CD150 trpl.) |
---|---|---|---|---|---|---|---|---|---|---|
2010 | 7.76 | LD50/30 | LD26/30 | 20 | X | |||||
7.96 | LD70/30 | LD26/30 | 8 | X | ||||||
7.96 | LD70/30 | LD50/30 | 58 | X | X | X | X | |||
2011 | 7.96 | LD70/30 | LD30/30 | 70 | X | |||||
7.86 | LD60/30 | LD20/30 | 16 | X | X | |||||
8.10 | LD80/30 | LD50/30 | 7 | X | X | X | ||||
8.29 | LD90/30 | LD30/30 | 27 | X | X | X | X | |||
7.92 | LD50/30 | LD35/30 | 13 | X | X | X | ||||
8.06 | LD70/30 | LD35/30 | 12 | X | X | X | X | |||
2012 | 8.53 | LD50/30 | LD77/30 | 4 | X | X | X | X | ||
2013 | 8.53 | LD50/30 | LD55/30 | 22 | X | X | X | X | ||
8.72 | LD70/30 | LD60/30 | 13 | X | X | X | X | |||
8.53 | LD50/30 | LD50/30 | 9 | X | X | X | X | |||
8.72 | LD70/30 | LD70/30 | 6 | X | X | X | X | |||
9.04 | LD90/30 | LD80/30 | 4 | X | X | X | X | |||
8.53 | LD50/30 | N/Dc | 6 | X | X | X | X | |||
8.53 | LD50/30 | LD40/30 | 11 | X | X | X | X | |||
8.72 | LD70/30 | LD90/30 | 2 | X | X | X | X | |||
8.53 | LD50/30 | LD49/30 | 42 | X | X | |||||
8.53 | LD50/30 | LD40/30 | 14 | X | X | |||||
8.72 | LD70/30 | LD73/30 | 10 | X | X | X | ||||
8.72 | LD70/30 | LD65/30 | 7 | X | X | X | ||||
9.27 | LD95/30 | LD95/30 | 1 | X | X | |||||
2014 | 8.53 | LD50/30 | LD65/30 | 12 | X | X | ||||
8.72 | LD70/30 | LD85/30 | 9 | X | X | X | X | |||
9.27 | LD95/30 | LD90/30 | 2 | X | X | X | ||||
8.53 | LD50/30 | LD40/30 | 12 | X | X | |||||
8.72 | LD70/30 | LD55/30 | 9 | X | X | X | ||||
8.53 | LD50/30 | LD50/30 | 25 | X | X | |||||
8.72 | LD70/30 | LD60/30 | 13 | X | X | |||||
2015 | 8.53 | LD50/30 | LD30/30 | 26 | X | |||||
8.72 | LD70/30 | LD80/30 | 10 | X | ||||||
8.72 | LD70/30 | LD75/30 | 10 | X | ||||||
8.72 | LD70/30 | LD81/30 | 15 | X | X | |||||
2016 | 9.04 | LD90/30 | LD90/30 | 14 | X | X | ||||
9.04 | LD90/30 | LD87/30 | 5 | X | X | X | ||||
8.72 | LD70/30 | LD78/30 | 9 | X | X | |||||
8.53 | LD50/30 | LD73/30 | 32 | X | ||||||
LDXX/30 were derived from three separate dose response relationship studies conducted in 2006, 2011, and 2012.
The total number of day 30 survivors utilized in studies in this paper was 585. These resulted from more than 1,500 mice irradiated on day 0.
A majority of mice underwent scheduled euthanasias prior to day 30, thus the actual LDXX/30 could not be determined.