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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Health Phys. 2019 Apr;116(4):546–557. doi: 10.1097/HP.0000000000000950

Table 1.

Year, radiation dose, expected and actual LDXX/30, number of mice, and parameters assessed in each study

Year  Rad
Dose
(Gy)
LDXX/30
(expected)a
LDXX/30
 (actual)
No. of
miceb
Fig. 1A
(Wt.)
Figs. 1B-F
(CBC)
Fig. 2
(BM)
Fig. 3
(HSC trpl.)
Figs. 4A-E
(Culture)
Figs. 4F-H
(CD150 trpl.)

2010 7.76  LD50/30 LD26/30 20 X
7.96  LD70/30 LD26/30  8 X
7.96  LD70/30 LD50/30 58 X X X X

2011 7.96  LD70/30 LD30/30 70 X
7.86  LD60/30 LD20/30 16 X X
8.10  LD80/30 LD50/30  7 X X X
8.29  LD90/30 LD30/30 27 X X X X
7.92  LD50/30 LD35/30 13 X X X
8.06  LD70/30 LD35/30 12 X X X X

2012 8.53  LD50/30 LD77/30  4 X X X X

2013 8.53  LD50/30 LD55/30 22 X X X X
8.72  LD70/30 LD60/30 13 X X X X
8.53  LD50/30 LD50/30  9 X X X X
8.72  LD70/30 LD70/30  6 X X X X
9.04  LD90/30 LD80/30  4 X X X X
8.53  LD50/30 N/Dc  6 X X X X
8.53  LD50/30 LD40/30 11 X X X X
8.72  LD70/30 LD90/30  2 X X X X
8.53  LD50/30 LD49/30 42 X X
8.53  LD50/30 LD40/30 14 X X
8.72  LD70/30 LD73/30 10 X X X
8.72  LD70/30 LD65/30  7 X X X
9.27  LD95/30 LD95/30  1 X X

2014 8.53  LD50/30 LD65/30 12 X X
8.72  LD70/30 LD85/30  9 X X X X
9.27  LD95/30 LD90/30  2 X X X
8.53  LD50/30 LD40/30 12 X X
8.72  LD70/30 LD55/30  9 X X X
8.53  LD50/30 LD50/30 25 X X
8.72  LD70/30 LD60/30 13 X X

2015 8.53  LD50/30 LD30/30 26 X
8.72  LD70/30 LD80/30 10 X
8.72  LD70/30 LD75/30 10 X
8.72  LD70/30 LD81/30 15 X X

2016 9.04  LD90/30 LD90/30 14 X X
9.04  LD90/30 LD87/30  5 X X X
8.72  LD70/30 LD78/30  9 X X
8.53  LD50/30 LD73/30 32 X

a

LDXX/30 were derived from three separate dose response relationship studies conducted in 2006, 2011, and 2012.

b

The total number of day 30 survivors utilized in studies in this paper was 585. These resulted from more than 1,500 mice irradiated on day 0.

c

A majority of mice underwent scheduled euthanasias prior to day 30, thus the actual LDXX/30 could not be determined.