Table 3b.
Change over time in telomere length, telomerase activity and plasma Aβ levels in older adults with subjective cognitive decline randomized to a 12-week Kirtan Kriya meditation (KK) or a 12-week music listening (ML) program
Outcome Measures | Change from Baseline (KK) |
Change from Baseline (ML) |
|||||
---|---|---|---|---|---|---|---|
3 months Mean (SE) |
p* | ES | 3 months Mean (SE) |
p* | ES | p‡ | |
Telomere length (absolute mean, kb) | 0.29 (2.23) | 0.38 | 0.27 | –2.25 (2.50) | 0.20 | 0.10 | 0.32 |
Telomerase activity (TSR8 copies) | 1048.88 (2733.45) | 0.71 | 0.10 | 1218.34 (1448.81) | 0.12 | 0.28 | 0.87 |
Plasma Aβ (pg/ml) | |||||||
Aβ38 | 3.33 (13.32) | 0.81 | 0.01 | 1.26 (9.08) | 0.57 | 0.01 | 0.64 |
Aβ40 | 2.04 (5.23) | 0.71 | 0.09 | –14.13 (7.16) | 0.06 | 0.27 | 0.04 |
Aβ42 | 0.42 (1.74) | 0.81 | 0.01 | 0.41 (0.41) | 0.63 | 0.04 | 0.77 |
Ratio Aβ42/Aβ40 | 0.001 (0.01) | 0.33 | 0.02 | 0.004 (0.001) | 0.01 | 0.14 | 0.098 |
Repeated measures ANOVA
Between group difference at 3 months (P’s and effect sizes calculated on log-transformed values, adjusted for age and baseline values). ES, effect size; SE, standard error.