Table 4.
Relation of changes over time in psychosocial status, quality of life, and cognitive function to those in blood biomarkers in older adults with subjective cognitive decline Change over time at 3 months
| Change over time at 3 months |
||||||
|---|---|---|---|---|---|---|
| Change from baseline | Telomere Length | Telomerase Activity | Aβ38 | Aβ40 | Aβ42 | Aβ42/Aβ40 ratio |
| At 3 months | ||||||
| Memory and Cognitive Performance | ||||||
| Memory Functioning Questionnaire | ||||||
| Total | 0.34* | 0.29(*) | 0.25(*) | |||
| Retrospective Memory | 0.31* | |||||
| Frequency of Forgetfulness | 0.41*** | 0.43*** | 0.31* | |||
| Seriousness of Forgetting | ||||||
| Mnemonic use | –0.25(*) | |||||
| Trail-making Test-A | –0.54* | –0.28(*) | ||||
| Trail-making Test-B | –0.40*** | |||||
| Digit Symbol Substitution Test | 0.26(*) | |||||
| Mood, stress, sleep and QOL | ||||||
| Mood (POMS) Total score | –0.53* | –0.41*** | ||||
| Perceived stress (PSS) | –0.29(*) | –0.32** | –0.29* | |||
| Emotional well-being (PWBS) | 0.32** | |||||
| Sleep quality (PSQI) Total Score | –0.54‡‡ | –0.33* | –0.48* | |||
| Sleep Latency | –0.31* | –0.29(*) | –0.36** | |||
| Sleep quality | –0.46*** | –0.25(*) | –0.35** | |||
| Sleep hours | 0.26(*) | |||||
| Health-related OOL (SF-36) | ||||||
| Mental Health Component | 0.38*** | 0.32* | ||||
| Role emotional | 0.29(*) | |||||
| Emotion wellbeing | 0.40*** | 0.36** | ||||
| Social function | 0.28(*) | 0.31* | 0.26(*) | |||
| Energy | 0.32* | 0.40‡ | 0.43* | 0.55‡‡ | 0.35** | |
| Physical Health Component | 0.33* | 0.26(*) | 0.41‡ | 0.42‡ | 0.28(*) | |
| General Health | 0.33* | 0.41*** | 0.31* | |||
| Pain | 0.26(*) | 0.27(*) | 0.26(*) | |||
| Physical function | 0.26(*) | 0.32* | ||||
| Role physical | 0.30* | 0.34* | 0.30* | |||
| At 6 months | ||||||
| Memory and Cognitive Performance | ||||||
| Memory Functioning Questionnaire | 0.42*** | 0.37*** | 0.28(*) | |||
| Total | ||||||
| Retrospective Memory | ||||||
| Frequency of Forgetfulness | 0.41‡ | 0.43*** | 0.30(*) | |||
| Seriousness of Forgetting | 0.31* | |||||
| Mnemonic use | ||||||
| Trail-making Test-A | –0.54* | –0.28(*) | ||||
| Trail-making Test-B | –0.30* | –0.39*** | ||||
| Digit Symbol Substitution Test | 0.26(*) | |||||
| Memory concerns at 6 mos¥ | –0.33* | –0.41‡‡ | –0.29(*) | |||
| Mood, stress, sleep and QOL | ||||||
| Mood (POMS) | –0.29(*) | –0.27(*) | ||||
| Perceived stress (PSS) | –0.43** | |||||
| Emotional well–being (PWBS) | 0.30* | 0.35** | ||||
| Sleep quality (PSQI) | –0.44*** | –0.39*** | –0.35** | |||
| Sleep Latency | –0.36** | –0.31* | –0.34* | |||
| Sleep quality | 0.27(*) | –0.54‡‡ | –0.39*** | –0.48‡ | ||
| Sleep meds | –0.31* | –0.42** | –0.30* | |||
| Health-related OOL (SF-36) | ||||||
| Mental Health Component | ||||||
| Physical Health Component | 0.51‡ | 0.50‡ | 0.38‡ | |||
(*)
p < 0.1
*
p < 0.05;
**
p < 0.025
***
p < 0.01
‡
p < 0.001
‡‡
p < 0.0001.
¥
Scored on a 5 point Likert scale from 1(much less concerned) to 5 (much more concerned). POMS, Profile of Mood States; PSQI, Pittsburgh Sleep Quality Index; PSS, Perceived Stress Scale; PWBS, Psychological Well-being Scale; QOL, Quality of Life.