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. Author manuscript; available in PMC: 2019 Feb 25.
Published in final edited form as: Microbiol Spectr. 2015 Aug;3(4):10.1128/microbiolspec.MDNA3-0040-2014. doi: 10.1128/microbiolspec.MDNA3-0040-2014

FIGURE 4.

FIGURE 4

Impact of Tf elements on gene expression. Tf element integration can activate the expression of adjacent genes. (A) Tf2 long terminal repeat (LTR) (blue) possesses a motif ATCGTACCAT bound by the transcription factor Sre1 (green), which activates the transcription of oxygen-dependent genes such as amt3. Pol II (pink); RNA polymerase II. (B) Sequences within the Tf1 LTR substitute for the elements in the ade6 promoter that are disrupted by Tf1 integration. Tf1 integration results in a 2.1- to 3.6-fold increase in ade6 expression. TF (grey): transcription factor. (C) Tf1 integration near the heat shock gene ssa1 acts as an enhancer of transcription, through a mechanism that may involve the transcription activation factor Atf1 (red). A motif TGACGT similar to the sequence bound by Atf1 is within the Tf1 LTR (blue). doi:http://10.1128/microbiolspec.MDNA3-0040-2014.f4