Growth inhibitory effects of 44 against MDA-MB-231, SK-BR3, MDA-MB-468, and MCF-7 breast cancer cells. (A) 44 significantly inhibits colony formation of MDA-MB-231, SK-BR3, MDA-MB-468, and MCF-7 cells. (B) 44 suppresses the proliferation of MDA-MB-231, SK-BR3, MDA-MB-468, and MCF-7 cells. Data are presented as the mean ± SD of at least three independent experiments. Significance between different groups was determined by using one-way ANOVA; p = 0.0003 (MDA-MB-231), p = 0.0002 (MDA-MB-468), p < 0.0001 (SK-BR3), and p = 0.0012 (MCF-7).