Table 2.
Analysis of visual analog scale (VAS) pain intensity score (modified intention-to-treat population)
| Time point | Adjusteda mean change from baseline
|
Estimated treatment effect (95% CI) | P-value | |
|---|---|---|---|---|
| Methoxyflurane (n=47) | Placebo (n=48) | |||
|
| ||||
| Overall | −29.0 | −19.1 | −9.9 (−17.4, −2.4) | 0.0104 |
| 5 minutes | −24.5 | −14.6 | −9.9 (−17.5, −2.2) | |
| 10 minutes | −28.1 | −18.8 | −9.3 (−17.2, −1.4) | |
| 15 minutes | −31.6 | −19.2 | −12.4 (−21.9, −2.9) | |
| 20 minutes | −31.7 | −23.7 | −8.0 (−17.4, 1.5) | |
Notes: Pain scores recorded following the start of the planned emergency department procedure were excluded from the analysis. Pain scores taken after initiation of rescue medication were included in the analysis.
a
Least squares mean adjusted for baseline VAS pain score and time by treatment interaction.