Table 1.
Duration, Indication, Prior Treatment, and Outcomes of Patients Receiving Dalbavancin
| Duration of Dalbavancin Therapy, wk | Weekly Dalbavancin Doses, mg | Successful Completion of Total Course | Type of Infection | Inpatient Antibiotics Used | No. of Days of Prior Antibiotic | Clinical Response | Reason for Dalbavancin Failure | |
|---|---|---|---|---|---|---|---|---|
| Planned | Actual | |||||||
| 5 | 5 | 1500, 1000, 500, 500, 500 | Yes | Osteomyelitis, extremity | Vancomycin, TMP-SMX | 10 | Yes | |
| 3 | 3 | 1500, 1000, 1000 | Yes | Bacteremia with infected thrombophlebitis | Vancomycin | 6 | Yes | |
| 2 | 2 | 1000, 500 | Yes | Osteomyelitis, extremity | Vancomycin | 1 | Yes | |
| 3 | 2 | 1000, 500 | No | Endocarditis | Ceftaroline | 4 | Yes | |
| 2 | 2 | 1000, 500 | No | Osteomyelitis, extremity | Vancomycin, doxycycline | 17 | Yes | |
| 2 | 2 | 1000, 500 | No | Endocarditis | Vancomycin | 8 | Yes | |
| 1 | 1 | 1000 | No | Bacteremia, flexor tenosynovitis | Vancomycin | 10 | Yes | |
| 1 | 1 | 1000 | Yes | Septic arthritis | Vancomycin | 8 | Yes | |
| 1 | 1 | 1000 | No | Endocarditis | Cefazolin | 24 | Yes | |
| 1 | 1 | 1000 | No | Osteomyelitis, spine | Vancomycin | 3 | Yes | |
| 1 | 1 | 1000 | Yes | Bacteremia | Vancomycin | 3 | Yes | |
| 1 | 1 | 1000 | Yes | Endocarditis | Vancomycin | 32 | Yes | |
| 1 | 1 | 1000 | Yes | Bacteremia | Vancomycin | 8 | Yes | |
| 1 | 1 | 500 | Yes | Bacteremia | Vancomycin | 7 | Yes | |
| 1 | 1 | 1000 | Yes | Osteomyelitis, spine | Vancomycin, ceftriaxone | 18 | Yes | |
| 1 | 1 | 1000 | No | Endocarditis, empyema | Vancomycin | 24 | Yes | |
| 2 | 1 | 1000 | No | Bacteremia | Vancomycin | 16 | Yes | |
| 1 | 1 | 1000 | Yes | Bacteremia | Vancomycin | 9 | Yes | |
| NA | 3 | 1000, 500, 500 | Yes | Septic arthritis, bacteremia | Vancomycin | 20 | No | Subsequent surgical debridement needed on day of first dalbavancin dose |
| 2 | 2 | 1000, 500 | No | Bacteremia with subdural & epidural abscess | Nafcillin | 12 | No | Development of vertebral osteomyelitis - 8 months later |
| 3 | 1 | 1000 | No | Osteomyelitis, spine | Vancomycin | 29 | No | Worsening back pain and bacteremia - 2 months later |
| 2 | 1 | 1000 | No | Osteomyelitis, extremity | Vancomycin | 10 | No | Subsequent surgical debridement needed - 4 months later |
| 2 | 2 | 1500, 500 | Yes | Endocarditis, infected thrombophlebitis | Vancomycin | 20 | Unknown | |
| 2 | 2 | 1000, 500 | Yes | Septic arthritis | Vancomycin | 14 | Unknown | |
| 1 | 1 | 1000 | Yes | Bacteremia with epidural phlegmon | Vancomycin | 8 | Unknown | |
| 1 | 1 | 1000 | Yes | Bacteremia | Vancomycin | 7 | Unknown | |
| 2 | 1 | 1000 | No | Bacteremia with epidural abscess | Vancomycin | 13 | Unknown | |
| 1 | 1 | 1000 | Yes | Bacteremia | Daptomycin | 13 | Unknown | |
| 2 | 1 | 1000 | No | Endocarditis | Cefazolin | 13 | Unknown | |
| 2 | 1 | 1000 | Yes | Endocarditis, empyema | Vancomycin | 17 | Unknown | |
| 2 | 1 | 1000 | No | Bacteremia with infected thrombophlebitis | Vancomycin, TMP/SMX | 11 | Unknown | |
| 2 | 1 | 1000 | No | Endocarditis | Vancomycin | 13 | Unknown | |
Abbreviation: TMP-SMX, trimethoprim/sulfamethoxazole.