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. 2018 Sep 12;105(3):235–242. doi: 10.1136/heartjnl-2018-313351

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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Efficacy of apixaban relative to warfarin for fragment 1+2 (F1+2) and D-dimer levels at 2 months (A). Efficacy of apixaban relative warfarin for soluble CD40 ligand (sCD40L) and von Willebrand factor (vWF) levels at 2 months (B). Cox proportional hazards model with biomarker level, treatment and interaction between biomarker level and treatment as covariates. CRNM, clinically relevant non-major; SE, systemic embolism.