Table 1. Change in 84 proteins over 10-year follow-up with measurements at ages 70, 75 and 80 years.
| Protein | Beta | SE | p-value |
|---|---|---|---|
| Adrenomedullin (AM) | .170 | .007 | 1.0e-122 |
| Urokinase plasminogen activator surface receptor (U-PAR) | .138 | .006 | 1.0e-104 |
| Osteoprotegerin (OPG) | .136 | .006 | 2.1e-101 |
| Interleukin-27 subunit alpha (IL27-A) | .130 | .006 | 8.0e-100 |
| N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) | .137 | .007 | 4.5e-93 |
| Tissue-type plasminogen activator (t-PA) | .149 | .007 | 7.9e-89 |
| Proteinase-activated receptor 1 (PAR-1) | .140 | .007 | 1.4e-84 |
| Caspase-8 (CASP-8) | -.140 | .008 | 1.9e-74 |
| Growth/differentiation factor 15 (GDF-15) | .102 | .006 | 1.0e-73 |
| Endothelial cell-specific molecule 1 (ESM-1) | .118 | .007 | 2.6e-69 |
| Fibroblast growth factor 23 (FGF-23) | .097 | .006 | 2.6e-62 |
| Pentraxin-related protein PTX3 (PTX3) | .131 | .008 | 2.2e-58 |
| Matrix metalloproteinase-12 (MMP-12) | .089 | .006 | 2.7e-56 |
| Vascular endothelial growth factor D (VEGF-D) | .105 | .007 | 2.0e-55 |
| Spondin-1 (SPON1) | .123 | .008 | 1.5e-53 |
| Agouti-related protein (AGRP) | .113 | .008 | 1.3e-47 |
| Fractalkine (CX3CL1) | .102 | .007 | 1.2e-42 |
| CD40L receptor (CD40) | .085 | .006 | 1.8e-42 |
| Proto-oncogene tyrosine-protein kinase Src (SRC) | .127 | .009 | 1.6e-41 |
| TNF-related apoptosis-inducing ligand (TRAIL) | .102 | .007 | 9.5e-41 |
| Heparin-binding EGF-like growth factor (HB-EGF) | .096 | .008 | 1.89e-33 |
| Hepatocyte growth factor (HGF) | .082 | .007 | 1.86e-32 |
| Kallikrein-6 (KLK6) | .089 | .008 | 1.28e-30 |
| ST2 protein (ST2) | .070 | .006 | 2.21e-30 |
| Interleukin-16 (IL-16) | .083 | .007 | 4.05e-30 |
| P-selectin glycoprotein ligand 1 (PSGL-1) | .094 | .01 | 3.83e-20 |
| Cystatin-B (CSTB) | .069 | .007 | 4.33e-20 |
| Vascular endothelial growth factor A (VEGF-A) | .067 | .007 | 6.80e-20 |
| Pappalysin-1 (PAPPA) | .064 | .007 | 7.54e-20 |
| Membrane-bound aminopeptidase P (mAmP) | -.039 | .004 | 2.41e-18 |
| Macrophage colony-stimulating factor 1 (CSF-1) | .069 | .008 | 8.27e-18 |
| Matrix metalloproteinase-1 (MMP-1) | -.053 | .007 | 3.34e-16 |
| Myeloperoxidase (MPO) | -.073 | .009 | 6.92e-16 |
| TNF-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) | .049 | .006 | 5.69e-15 |
| Lectin-like oxidized LDL receptor 1 (LOX-1) | .071 | .009 | 4.20e-14 |
| Epidermal growth factor (EGF) | -.073 | .01 | 9.41e-14 |
| Follistatin (FS) | .061 | .009 | 8.49e-12 |
| Protein S100-A12 (EN-RAGE) | -.067 | .01 | 2.43e-11 |
| Eosinophil cationic protein (ECP) | .051 | .008 | 2.84e-11 |
| Interleukin-6 (IL-6) | .054 | .008 | 3.79e-11 |
| Receptor for advanced glycosylation end products (RAGE) | .040 | .006 | 1.34e-10 |
| Cathepsin L1 (CTSL1) | -.066 | .01 | 1.66e-10 |
| C-C motif chemokine 20 (CCL20) | .060 | .009 | 1.85e-10 |
| TNF-related activation-induced cytokine (TRANCE) | -.051 | .008 | 7.73e-10 |
| Placenta growth factor (PlGF) | .043 | .007 | 2.09e-09 |
| Platelet-derived growth factor subunit B (PDGF subunit B) | -.043 | .008 | 1.65e-08 |
| Kallikrein-11 (hK11) | .051 | .009 | 1.88e-08 |
| Tissue factor (TF) | .047 | .008 | 2.04e-08 |
| Leptin (LEP) | -.029 | .005 | 2.49e-08 |
| Monocyte chemotactic protein 1 (MCP-1) | .048 | .009 | 3.09e-08 |
| Fatty acid-binding protein 4 (FABP4) | -.028 | .006 | 9.94e-07 |
| Interleukin-6 receptor subunit alpha (IL-6RA) | .030 | .006 | 1.25e-06 |
| Chitinase-3-like protein 1 (CHI3L1) | .035 | .007 | 1.93e-06 |
| C-X-C motif chemokine 6 (CXCL6) | -.036 | .008 | 2.20e-06 |
| Matrix metalloproteinase-3 (MMP-3) | -.029 | .006 | 2.78e-06 |
| Galectin-3 (Gal-3) | .031 | .007 | 3.28e-06 |
| Tumor necrosis factor receptor 2 (TNF-R2) | .030 | .007 | 3.63e-06 |
| T-cell immunoglobulin and mucin domain 1 (TIM-1) | .024 | .005 | 6.52e-06 |
| Tumor necrosis factor receptor 1 (TNF-R1) | .029 | .007 | 9.51e-06 |
| Tumor necrosis factor ligand superfamily member 14 (TNFSF14) | .039 | .009 | .0000183 |
| Platelet endothelial cell adhesion molecule (PECAM-1) | .032 | .008 | .0000241 |
| C-C motif chemokine 4 (CCL4) | .027 | .007 | .0002472 |
| Interleukin-1 receptor antagonist protein (IL-1RA) | -.025 | .008 | .0031852 |
| Angiopoietin-1 receptor (TIE2) | -.023 | .008 | .0054946 |
| Growth hormone (GH) | .028 | .01 | .0065182 |
| E-selectin (SELE) | -.015 | .006 | .0075581 |
| Thrombomodulin (TM) | -.018 | .007 | .0076076 |
| Resistin (RETN) | -.020 | .008 | .0077487 |
| C-X-C motif chemokine 16 (CXCL16) | .020 | .009 | .0252256 |
| Tumor necrosis factor receptor superfamily member 6 (FAS) | .018 | .008 | .0260263 |
| Myoglobin (MB) | .019 | .008 | .0261793 |
| Galanin peptides (GAL) | .011 | .006 | .0564566 |
| C-X-C motif chemokine 1 (CXCL1) | -.013 | .007 | .0733593 |
| C-C motif chemokine 3 (CCL3) | .012 | .007 | .1115752 |
| Prolactin (PRL) | .010 | .007 | .1855251 |
| Interleukin-18 (IL-18) | -.009 | .007 | .1974891 |
| Cathepsin D (CTSD) | .008 | .007 | .2256375 |
| Interleukin-8 (IL-8) | -.011 | .009 | .2643662 |
| Matrix metalloproteinase-10 (MMP-10) | .010 | .009 | .267806 |
| Dickkopf-related protein 1 (DKK-1) | -.008 | .007 | .3007548 |
| Ovarian cancer-related tumor marker CA 125 (CA-125) | .006 | .006 | .367675 |
| Heat shock 27 kDa protein (HSP 27) | .008 | .01 | .4298231 |
| Renin (REN) | .003 | .005 | .5746617 |
| Stem cell factor (SCF) | .001 | .006 | .8936469 |
The betas show the direction and magnitude of the change per year on a SD scale (to increase cross-comparability). P< 0.00059 is regarded as significant (Bonferroni-correction for 84 proteins).