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. 2019 Feb 14;11:1517–1524. doi: 10.2147/CMAR.S176762

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© 2019 Lin et al. This work is published and licensed by Dove Medical Press Limited

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Plk3 knockdown reduces prostate cancer cell proliferation.

Notes: (A) Western blotting verification of si-Plk3 knockdown efficiency of DU145 cells. (B) GSEA of proliferation-associated gene set in Plk3 high (H) and low (L) expression groups. The samples were classified into low (mRNA expression <136) or high (mRNA expression >136) based on the average. (C) MTS assay evaluation of influence of Plk3 knockdown on DU145 viability. (D) Colony formation assay determining the effect of Plk3 knockdown in DU145 cells. (E) FCM assay evaluation of influence of Plk3 knockdown on DU145 apoptosis. The data are presented as mean ± SD. *P<0.05 and **P<0.01.

Abbreviations: Ctrl, control; FCM, flow cytometry; GSEA, Gene Set Enrichment Analysis; n.s., no significance; Plk3, polo-like kinase 3.