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. 2019 Feb 19;12:1365–1377. doi: 10.2147/OTT.S192069

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© 2019 Zhu et al. This work is published and licensed by Dove Medical Press Limited

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MALAT1 downregulation repressed the proliferation, migration, and invasion by regulating miR-140-5p in TSCC cells.

Notes: (A and B) RT-qPCR assay was used to measure the expression of miR-140-5p in Tca8113 and SCC-9 cells after transfection with anti-miR-NC or anti-miR-140-5p. Untransfected cells served as the negative control group. (C–F) Tca8113 and SCC-9 cells were transfected with si-MALAT1, or together with anti-miR-140-5p, followed by CCK-8 analysis of cell proliferation (C and D), as well as Transwell assay of cell migration (E) and invasion (F). ^*P<0.05.

Abbreviations: CCK-8, Cell Counting Kit-8; RT-qPCR, quantitative reverse transcriptase PCR; si-MALAT1, siRNA targeting MALAT1; si-NC, scrambled control siRNA; TSCC, tongue squamous cell carcinoma; Con, negative control.

MALAT1 downregulation repressed the proliferation, migration, and invasion by regulating miR-140-5p in TSCC cells.

Notes: (A and B) RT-qPCR assay was used to measure the expression of miR-140-5p in Tca8113 and SCC-9 cells after transfection with anti-miR-NC or anti-miR-140-5p. Untransfected cells served as the negative control group. (C–F) Tca8113 and SCC-9 cells were transfected with si-MALAT1, or together with anti-miR-140-5p, followed by CCK-8 analysis of cell proliferation (C and D), as well as Transwell assay of cell migration (E) and invasion (F). ^*P<0.05.

Abbreviations: CCK-8, Cell Counting Kit-8; RT-qPCR, quantitative reverse transcriptase PCR; si-MALAT1, siRNA targeting MALAT1; si-NC, scrambled control siRNA; TSCC, tongue squamous cell carcinoma; Con, negative control.