Figure 6.

Tiam1 depletion reduces angiogenesis and cancer cell VM capacities.

Notes: (A) Relative expression levels of VEGF and VEGFA in A549 and H1975 cells with si-control or si-Tiam1, respectively. (B) Endothelial tube formation assay was performed with HUVECs incubated in culture medium of A549 and H1975 cancer cells 48 hours after transfection with the si-control and si-Tiam1. The VM assay was performed with A549 and H1975 cancer cells with si-control or si-Tiam1, respectively (original magnification, 100×).

Abbreviations: HUVECs, human umbilical vein endothelial cells; VM, vasculogenic mimicry.