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. 2019 Feb 20;15:531–542. doi: 10.2147/NDT.S193125

Figure 2.

Figure 2

E177 attenuated DIZ-induced memory deficits in the IAP.

Notes: Average STL time measured on the first training day before the delivery of foot shock (white columns), and average STL time measured on the test day (black columns). Acute systemic administration of E177 at different doses (1.25, 2.5, 5, and 10 mg/kg i.p.) or DOZ (1 mg/kg i.p.) 30–45 minutes before the test session. #P<0.0001 for average STL time compared with that in the saline-treated group. *P<0.0001 for average STLs compared with the DIZ-treated group. &P<0.0001 compared with the DOZ-treated group. $P<0.05 compared with the DOZ-treated group. The data are expressed as the mean ± SEM (n=7).

Abbreviations: DIZ, dizocilpine; DOZ, donepezil; IAP, inhibitory avoidance paradigm; i.p., intraperitoneally; SAL, saline; SEM, standard error of the mean; STL, step-through latency.