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. 2019 Feb 20;15:531–542. doi: 10.2147/NDT.S193125

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© 2019 Alachkar et al. This work is published and licensed by Dove Medical Press Limited

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RAMH reversed E177-induced memory enhancement of the DIZ-induced deficit in the IAP.

Notes: Average of STL time measured on the first training day before the delivery of foot shock (white columns), and average of the STL time measured on the test day (black columns). Acute systemic administration of E177 (5 mg/kg, i.p.), RAMH, and E177 (5 mg/kg) + RAMH (10 mg/kg) for 15–20 minutes (for RAMH) or 30–45 minutes (for H3R antagonist E177) before the test session. ^#P<0.001 average STLs compared with the saline-treated group. *P<0.001 for the average STL time compared with that in the DIZ-treated group. The data are expressed as the mean ± SEM (n=7).

Abbreviations: DIZ, dizocilpine; IAP, inhibitory avoidance paradigm; i.p., intraperitoneally; RAMH, R-(α)-methyl-histamine dihydrochloride; SAL, saline; SEM, standard error of the mean; STL, step-through latency.