Table 2.
Effects of acute systemic administration of E177 on anxiety levels and locomotor activity in the OFT
| Groups | Time for locomotion (seconds) | Distance traveled (cm) | Time in center (seconds) | Time in periphery (seconds) | No. of rearingevents | No. of grooming events |
|---|---|---|---|---|---|---|
| Saline | 99.67±6.47 | 1,003.33±51.34 | 1.67±0.19 | 78.67±6.40 | 18.17±2.41 | 2.00±0.58 |
| E177 (5 mg/kg) | 98.33±4.78 | 1,085.67±33.95 | 1.83±0.15 | 76.67±3.93 | 16.17±1.79 | 1.50±0.39 |
| E177 (10 mg/kg) | 100.86±8.16 | 999.86±52.44 | 1.71±0.26 | 77.14±7.87 | 15.14±2.54 | 1.86±0.31 |
| DOZ (1 mg/kg) | 109.83±5.31 | 1,022.67±44.65 | 1.50±0.20 | 71.33±6.63 | 16.67±2.55 | 0.67±0.45 |
Notes: E177 (5 and 10 mg/kg, i.p.) failed to alter time spent in the center arena, time spent in the periphery, total time spent for locomotion, total distance traveled, occurrence of rearing, and incidence of grooming. The data are expressed as the mean ± SEM (n=6–7).
Abbreviations: DOZ, donepezil; i.p., intraperitoneally; OFT, open-field test; SEM, standard error of the mean.