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. 2019 Feb 18;12:1279–1291. doi: 10.2147/OTT.S192364

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© 2019 Han et al. This work is published and licensed by Dove Medical Press Limited

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BVES/POPDC1 structure.

Notes: BVES/POPDC1 protein consists of an extracellular N-terminus, a three- pass transmembrane domain, and an intracellular C-terminus containing the highly conserved Popeye domain. BVES/POPDC1 directly binds to cAMP, VAMP3, and Cav3 in the Popeye domain, directly interacts with DNRG4 and PR61α in the intracellular C-terminus outside of Popeye domain, and directly interacts with ZO-1, GEFT, and TREK-1 in the intracellular C-terminus both inside and outside of Popeye domain.