Table 2.
Associations of KL expression and DNA methylation with clinicopathologic variables
| KL expression | KL methylation | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Variable | n | Low | Medium | High | P-value | P-trend | Low | Medium | High | P-value | P-trend |
| Gender | 521 | 0.271 | 0.394 | 0.012 | 0.04 | ||||||
| Female | 137 | 39 (28.5)a | 52 (38.0) | 46 (33.6) | 32 (23.4) | 56 (40.9) | 49 (35.8) | ||||
| Male | 384 | 135 (35.2) | 121 (31.5) | 128 (33.3) | 141 (36.7) | 118 (30.7) | 125 (32.6) | ||||
| Race | 506 | 0.672 | 0.390 | 0.775 | 0.736 | ||||||
| Caucasian | 446 | 146 (32.7) | 148 (33.2) | 152 (34.1) | 148 (33.2) | 152 (34.1) | 146 (32.7) | ||||
| Other | 60 | 23 (38.3) | 19 (31.7) | 18 (30.0) | 20 (33.3) | 18 (30.0) | 22 (36.7) | ||||
| Smoking | 508 | 0.282 | 0.270 | 0.288 | 0.115 | ||||||
| No | 117 | 37 (31.6) | 34 (29.1) | 46 (39.2) | 33 (28.2) | 39 (33.3) | 45 (38.5) | ||||
| Yes | 391 | 131 (33.5) | 136 (34.8) | 124 (31.7) | 137 (35.0) | 130 (33.3) | 124 (31.7) | ||||
| Stage | 507 | 0.183 | 0.039 | 0.520 | 0.141 | ||||||
| I | 20 | 3 (15.0) | 8 (40.0) | 9 (45.0) | 6 (30.0) | 8 (40.0) | 6 (30.0) | ||||
| II | 98 | 26 (26.5) | 32 (32.7) | 40 (40.8) | 29 (29.6) | 34 (34.7) | 35 (35.7) | ||||
| III | 105 | 42 (40.0) | 31 (29.5) | 32 (30.5) | 30 (28.6) | 33 (31.4) | 42 (40.0) | ||||
| IV | 284 | 97 (34.2) | 98 (34.5) | 89 (31.3) | 105 (37.0) | 93 (32.8) | 86 (30.3) | ||||
| Grade | 517 | 0.779 | 0.223 | 0.0009 | 0.0006 | ||||||
| I | 63 | 24 (38.1) | 22 (34.9) | 17 (27.0) | 17 (27.0) | 16 (25.4) | 30 (47.6) | ||||
| II | 304 | 101 (33.2) | 102 (33.6) | 101 (33.2) | 86 (28.3) | 115 (37.8) | 103 (33.9) | ||||
| III | 150 | 47 (31.3) | 49 (32.7) | 54 (36.0) | 67 (44.7) | 42 (28.0) | 41 (27.3) | ||||
| Tumor site | 521 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | ||||||
| Tongue | 200 | 52 (26.0) | 60 (30.0) | 88 (44.0) | 79 (39.5) | 72 (36.0) | 49 (24.5) | ||||
| Pharynx | 135 | 39 (28.9) | 52 (38.5) | 44 (32.6) | 53 (39.3) | 45 (33.3) | 37 (27.4) | ||||
| Other | 186 | 83 (44.6) | 61 (32.8) | 42 (22.6) | 41 (22.0) | 57 (30.7) | 88 (47.3) | ||||
Note:
a
n (%).