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. 2019 Feb 19;11:1667–1683. doi: 10.2147/CMAR.S186956

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© 2019 Zehra et al. This work is published and licensed by Dove Medical Press Limited

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(A) The gene expression analysis of osteopontin in response to the treatment with betulin after 48 hours as observed via RT-PCR. The results show pronounced downregulation of expression of the marker in comparison to GAPDH, the reference gene. (B) Proteomic analysis of osteopontin compared with the untreated control studied through immunofluorescence assay under fluorescent microscope at 20× magnification. The expression of osteopontin in the cells after the treatment. (C) Proposed mechanism of osteopontin as central regulator of apoptosis and metastasis in H460 cells.

Abbreviation: MMP, matrix metalloproteinases.