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. 2019 Feb 19;11:1653–1665. doi: 10.2147/CMAR.S188248

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© 2019 Zhang et al. This work is published and licensed by Dove Medical Press Limited

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FGG promotes HCC cell migration and invasion.

Notes: (A, D) Western blot results showing that FGG was overexpressed or knocked down in SK-Hep-1 cells. (B) Representative images reflect that overexpression of FGG enhances the migration and invasion of SK-HEP-1 cells. (E) Knockdown of FGG suppresses the migration and invasion of HCC cells. (C, F) Quantitative analysis of migration and invasion data of SK-HEP-1 cells with FGG overexpression (C) or knockdown (F). (G) Wound healing assays show that overexpression of FGG promoted the migration of SK-HEP-1 cells. (H) Wound healing assays show that downregulation of FGG inhibited the migration of SK-HEP-1 cells. Representative images of wound healing assays were taken from 0 to 24 h after the scratch was made. All experiments were independently repeated at least three times. Data are shown as mean ± SD. ^*P<0.05, ^**P<0.01.

Abbreviations: CTRL, control; FGG, fibrinogen gamma chain; HCC, hepatocellular carcinoma; siFGG, knockdown of FGG with small interfering RNA duplexes.