Table 2.
Altered canonical pathways in each group
| -Log (p value) | Ratio | z-score | Molecules | |
|---|---|---|---|---|
| Altered pathways in ALDH2 high-expressed group | ||||
| Role of NFAT in regulation of the immune response | 4.82E00 | 2.34E−01 | 3.157 | BLNK,CD247,RAF1,HLA-DOA,CD3E,CD4,GNA11,FCER1A,HLA-DQA1 |
| Cdc42 signaling | 3E00 | 2.04E−01 | −2.828 | CD247,RAF1,HLA-DOA,MAP3K11,CD3E,ARPC1B,HLA-DQA1,CDC42EP2 |
| Lymphotoxin β receptor signaling | 1.32E00 | 2.04E−01 | 2.714 | IKBKB,MAP3K14,VCAM1,AKT1,CASP9,LTA,PIK3CG,LTB,IKBKE,PIK3CB |
| RhoA signaling | 4.37E−01 | 1.31E−01 | −2.309 | NEDD4,CFL1,NRP2,ARPC1B,ANLN,GNA12,RTKN |
| Intrinsic prothrombin activation pathway | 5.98E−01 | 1.72E−01 | −2.236 | COL1A2,COL1A1,COL5A3,COL10A1,COL3A1 |
| Altered pathways in SOD2 high-expressed group | ||||
| TREM1 signaling | 8.12E00 | 2.27E−01 | 3.638 | RELA,CXCL8,TREM1,NLRP3,PLCG1,IL6,CCL3,NOD2,CCL2,CASP1 |
| PPAR signaling | 3.95E00 | 1.4E−01 | −3.606 | RELA,IL36G,IL1A,NRAS,RRAS2,NFKBIA,HSP90AB1,PPARD,IL1B |
| PI3K/AKT signaling | 3.78E00 | 1.22E−01 | 2.324 | TSC1,RELA,NRAS,YWHAH,PIK3R1,MAP3K5,ITGA3,NFKBIA,RRAS2 |
| Protein kinase A signaling | 3.16E00 | 7.77E−02 | −2.294 | RELA,YWHAH,PDE7A,PTPN2,ANAPC10,PTPN12,GNG7,PHKA2,GNB3 |
| TNFR1 signaling | 1.83E00 | 1.22E−01 | 2.236 | RELA,NFKBIA,TNFAIP3,NFKBIB,TNF,CASP7 |
| IL-1 signaling | 3.45E00 | 1.32E−01 | 2.121 | RELA,IL1A,GNB3,NFKBIA,GNA15,GNB2,ADCY6,IRAK3,NFKBIB,GNG5 |