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. 2017 Oct 18;18:805. doi: 10.1186/s12864-017-4198-0

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Cross-sectional coefficient vs longitudinal coefficient for each CpG site under investigation longitudinally. The panels display the results for TSQ_L category 1, category 2, category 3 and category 4, respectively. The longitudinal coefficients represent the rates of change of methylation M-value per year relative to never smokers. The cross-sectional coefficients represent the baseline difference in methylation M-value compared to never smokers