. 2018 Feb 27;18:27. doi: 10.1186/s12871-018-0489-5

Table 2.

Summary of serum PEA, OEA, AEA, 2-AG, and cortisol levels at baseline and 4 h after TKA surgery. Group by time interactions for each metabolite are also shown

	Time	Placebo			Morphine			Estimated Mean Difference in Change Over Time (95% Confidence Interval)	P-value (ANOVA Interaction)
	Time	Mean	SD	N	Mean	SD	N
PEA	Baseline	1.561	0.481	17	1.452	0.497	15	−1.310 (−2.237, −0.382)	0.0048
PEA	4 h post-op	2.194	1.386	17	0.775	0.184	15	−1.310 (−2.237, −0.382)	0.0048
OEA	Baseline	2.101	1.009	18	1.201	0.484	15	−0.819 (−1.712, 0.073)	0.0706
OEA	4 h post-op	2.392	1.438	18	0.673	0.245	15	−0.819 (−1.712, 0.073)	0.0706
AEA	Baseline	0.260	0.139	18	0.089	0.055	15	−0.014 (−0.116, 0.089)	0.7856
AEA	4 h post-op	0.223	0.144	18	0.038	0.023	15	−0.014 (−0.116, 0.089)	0.7856
2-AG	Baseline	3.502	1.605	18	1.499	1.465	15	−2.286 (−6.617, 2.145)	0.3008
2-AG	4 h post-op	8.568	6.932	18	4.279	5.282	15	−2.286 (−6.617, 2.145)	0.3008
Cortisol	Baseline	13.250	7.176	16	14.025	5.528	14	−13.730 (−23.602, −3.859)	0.0081
Cortisol	4 h post-op	22.937	13.712	16	9.981	6.650	14	−13.730 (−23.602, −3.859)	0.0081