Fig. 1.

Experimental setup of the study. Diffusion kurtosis imaging (DKI) was performed in three cohorts of male wild-type (WT) and APP/PS1 mice at 2, 4 and 6 months of age, and these mice were sacrificed for histological analysis thereafter. In a fourth, longitudinal cohort of male WT and APP/PS1 mice, we performed DKI at 2, 4, 6 and 8 months of age and thereafter killed these mice for histological analysis