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. 2018 Feb 26;17:67. doi: 10.1186/s12943-018-0808-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Kaplan-Meier plots of the association of the presence of cfDNA PIK3CA mutations with RFS; a and BCSS; b in the entire cohort and the presence of cfDNA PIK3CA mutations with TTF in less than the 5th line; c more than the 5th line; d, and the presence of cfDNA ESR1 mutations with TTF in less than the 5th line; e and more than the 5th line; f in the entire cohort. The presence of cfDNA PIK3CA mutations and cfDNA ESR1 mutations were defined as either positive or negative. Abbreviations: cfDNA, cell-free DNA; RFS, relapse-free survival; BCSS, breast cancer-specific survival; TTF, time to treatment failure