Fig. 1.

Three classes of ADAS-cog trajectories (higher score is associated with lower cognitive function/greater decline) in participants from placebo or no treatment arms of clinical trials/studies. a Disease progression trajectories estimated by our latent class mixed model, where an increase in ADAS-cog scores (y axis) indicates worsening of cognitive function. b–d Individual participant trajectories for each of the three resulting classes (each line represents a single participant). Bold lines represent a smoothing of the data; shaded areas represent the 0.95 confidence interval. ADAS-cog Alzheimer’s Disease Assessment Scale—cognitive subscale