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. 2018 Feb 26;17:32. doi: 10.1186/s12934-018-0881-3

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Structural depictions of the alternative scaffold proteins discussed in the scope of this review. Structures were prepared from pdb identifiers 1IGT (IgG), 4GHK (vNAR), 5HDO (VHH), 3G3B (Variable Lymphocyte Receptor), ITTG (fibronectin domain III), 1SSO (Sso7d), 1HA9 (oMCoTI-II; knottin), 2XEE (DARPin), 1HPK (kringle domain), 2WNM (Gp2) and 1ILW (pyrazinamidase) using UCSF Chimera [133]. The proportions of the depicted scaffold proteins are relative and do not reflect the actual differences in size. Secondary structures are colored in red (helices) and blue (β-strands). Distinct hypervariable loops discussed in the scope of vNAR and VHH scaffolds are annotated