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Predicted tumor cellularity map. Left, voxelwise linear regression model was applied to multimodal preoperative MRI trained on automated cell counts of biopsies localized to different regions on MR image and used to generate a map of predicted cellularity (red areas signify more cells). Right, photomicrographs of biopsy specimens from regions of tumor with high and low cellularity (hematoxylin-eosin stain; original magnification, ×400). (Reprinted, with permission, from reference 91.)
